2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation Cell Cycle/DNA Damage
  3. Peptide-Drug Conjugates (PDCs) PSMA Folate Receptor (FR)
  4. CBP-1018

CBP-1018 is a PDC (peptide-drug conjugate) formed by conjugating Monomethyl auristatin E (HY-15162) to a dual-targeting ligand of FLOR1/PSMA (prostate-specific membrane antigen) via a linker (HY-78738). CBP-1018 binds to FLOR1 and prostate-specific membrane antigen (PSMA). CBP-1018 is applicable to the research of solid tumors and metastatic castration-resistant prostate cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CBP-1018

CBP-1018 Chemical Structure

CAS No. : 2923068-30-6

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Based on 1 publication(s) in Google Scholar

CBP-1018 Related Antibodies

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Description

CBP-1018 is a PDC (peptide-drug conjugate) formed by conjugating Monomethyl auristatin E (HY-15162) to a dual-targeting ligand of FLOR1/PSMA (prostate-specific membrane antigen) via a linker (HY-78738). CBP-1018 binds to FLOR1 and prostate-specific membrane antigen (PSMA). CBP-1018 is applicable to the research of solid tumors and metastatic castration-resistant prostate cancer[1][2].

In Vitro

CBP-1018 exhibits connexin-dependent instability in plasma[1].
CBP-1018 binds to FLOR1 and prostate-specific membrane antigen (PSMA)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CBP-1018 Related Antibodies
Clinical Trial
Molecular Weight

2839.18

Formula

C132H192N30O38S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (35.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3522 mL 1.7611 mL 3.5221 mL
5 mM 0.0704 mL 0.3522 mL 0.7044 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3522 mL 1.7611 mL 3.5221 mL 8.8054 mL
5 mM 0.0704 mL 0.3522 mL 0.7044 mL 1.7611 mL
10 mM 0.0352 mL 0.1761 mL 0.3522 mL 0.8805 mL
15 mM 0.0235 mL 0.1174 mL 0.2348 mL 0.5870 mL
20 mM 0.0176 mL 0.0881 mL 0.1761 mL 0.4403 mL
25 mM 0.0141 mL 0.0704 mL 0.1409 mL 0.3522 mL
30 mM 0.0117 mL 0.0587 mL 0.1174 mL 0.2935 mL
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CBP-1018 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBP-10182923068-30-6CBP1018CBP 1018Peptide-Drug Conjugates (PDCs)PSMAFolate Receptor (FR)Prostate-specific membrane antigentumor cellscathepsin BLC-MS/MShuman plasmasolid tumorsmetastatic castration resistant prostate cancerfolate receptor 1FLOR1prostate-specific membrane antigenInhibitorinhibitorinhibit

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