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Art. -Nr.: HY-P11969

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10YX

10YX is a cyclic peptide probe targeting glypican-3 (GPC3) (K_d = 300.4 nM for human GPC3). It achieves tumor targeting by binding to GPC3 sitemap2 and serves as a PET imaging probe for tumor visualization and intrahepatic lesion localization. 10YX is useful for research on hepatocellular carcinoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₈₃H₁₂₄N₂₂O₂₅S₂
Molecular Weight:1894.14

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

10YX Chemical Structure

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Preis

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Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

10YX (10 μM) binds to recombinant human GPC3 with a dissociation constant (K_d) of 300.4 nM^[1].
10YX binds to the predicted GPC3 binding site, and the highest-ranked docking conformation has a score of -6.664^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

10YX (200-300 μCi; i.v.) shows limited tumor uptake with a peak of 2.36% ID/mL at 10 min post-injection and a retention time of only 30 min in the HepG2 xenograft model^[1].
10YX (150-200 μCi; i.v.) exhibits a peak tumor uptake of 2.73% ID/g at 30 min and higher renal retention (45.41% ID/g at 4 h) in HepG2 tumor-bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Liver Cancer Modeling

Chemical Information

Molecular Weight 1894.14
Formel C₈₃H₁₂₄N₂₂O₂₅S₂
Sequence

AC-{Lys(PAMBA-DOTA)}-Cys-Leu-Asn-His-Glu-Leu-Phe-Gln-Thr-Cys-NH2 (Disulfide bridge: Cys2-Cys11)
Sequence Shortening

AC-{Lys(PAMBA-DOTA)}-CLNHELFQTC-NH2 (Disulfide bridge: Cys2-Cys11)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Chen G, et al. 10P3Me: A GPC3-Targeted Peptide PET Probe for Subcutaneous and Orthotopic HCC Imaging. J Med Chem. 2025 Sep 25;68(18):19714-19725. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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