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Art. -Nr.: HY-N12087

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8-Deoxylactucin

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8-Deoxylactucin is an orally active sesquiterpene lactone. 8-Deoxylactucin inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages with an IC₅₀ value of 4.35 μM. 8-Deoxylactucin exerts anti-inflammatory effects by blocking the NF-κB pathway. 8-Deoxylactucin demonstrates hepatoprotective efficacy in LPS/D-galactosamine-induced acute hepatitis model of mice. 8-Deoxylactucin can be used for the study of inflammatory diseases and inflammatory liver injuries.

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Reinheit: 95.0%
CAS. Nr.: 65725-10-2
Formel: C₁₅H₁₆O₄
Molecular Weight:260.29

Speicherung:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

8-Deoxylactucin Chemical Structure

CAS. Nr.: 65725-10-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Alle NO Synthase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
KB	ED₅₀	3.1 μM Compound: deoxyLactucin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 18329753]

In Vitro

8-Deoxylactucin (1 h pretreatment) significantly inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages, with an IC₅₀ of 4.35 μM^[1].
8-Deoxylactucin (1-10 μM, 1 h pretreatment) significantly reduces LPS-induced mRNA and protein expression of iNOS, as well as mRNA expression of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α in RAW264.7 cells^[1].
8-Deoxylactucin (1-10 μM, 2 h pretreatment) significantly blocks LPS-induced phosphorylation of IKKα/β and IκBα, inhibits IκBα degradation, and reduces nuclear accumulation of NF-κB p65 in RAW264.7 macrophages^[1].
8-Deoxylactucin (1-10 μM, 1 h pretreatment) significantly enhances protein expression and nuclear translocation of NRF2, up-regulates protein expression of NRF2-targeted antioxidant genes (HO, NQO1), and reduces ROS production in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

RAW264.7 macrophages
Concentration:

1, 5, 10 μM
Incubation Time:

1, 2 h pretreatment
Result:

Reduced the mRNA expression of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α in RAW264.7 cells.

Western Blot Analysis^[1]

Cell Line:

RAW264.7 macrophages
Concentration:

1, 5, 10 μM
Incubation Time:

1, 2 h pretreatment
Result:

Reduced LPS-induced expression of iNOS.
Blocked LPS-induced phosphorylation of IKKα/β and IκBα.
Inhibited IκBα degradation.
Reduced nuclear accumulation of NF-κB p65.

In Vivo

8-Deoxylactucin (2-10 mg/kg, i.g., once daily, 5 days) significantly reduces LPS/D-galactosamine (D-GalN)-induced increase in liver index (liver weight/body weight) in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS/D-galactosamine (D-GalN) (LPS: 50 μg/kg, D-GalN: 700 mg/kg, i.p. injection) was administered to 6-week-old male ICR mice (22-24 g) to induce acute hepatitis model^[1]
Dosage:

2, 5, 10 mg/kg
Administration:

i.g., once daily, 5 days
Result:

Achieved significant reduction in liver index.
Showed significant alleviation of liver tissue damage and decreased pathological scores.
Reduced serum ALT and AST levels.
Decreased protein expression of IL-1β, IL-6, TNF-α, and 4-HNE in liver tissues.

Chemical Information

CAS. Nr. 65725-10-2
Appearance Oil
Molecular Weight 260.29
Formel C₁₅H₁₆O₄
Color Off-white to light brown
SMILES

OCC([C@]1([H])[C@]2([H])[C@](CCC(C)=C13)([H])C(C(O2)=O)=C)=CC3=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhou Y, et al. Sesquiterpene lactones from Cichorium intybus exhibit potent anti-inflammatory and hepatoprotective effects by repression of NF-κB and enhancement of NRF2. J Ethnopharmacol. 2025 Mar 13;343:119439. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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8-Deoxylactucin

Alle NF-κB Isoform-spezifische Produkte anzeigen

Alle NO Synthase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

8-Deoxylactucin Related Classifications

HY-N12087 Related Classifications