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Art. -Nr.: HY-113455

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9(S)-HODE

(Synonyms: Alpha-dimorphecolic acid)

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9(S)-HODE (Alpha-dimorphecolic acid) is the major active derivative of Linoleic acid (HY-N0729). 9(S)-HODE regulates the expression of miR-361-3p. 9(S)-HODE reduces cancer cell viability and induces cancer cell apoptosis. 9(S)-HODE can be used in the research of acute myeloid leukemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98%
CAS. Nr.: 73543-67-6
Formel: C₁₈H₃₂O₃
Molecular Weight:296.44

Speicherung:

Solution, -20°C, 2 years

9(S)-HODE Chemical Structure

CAS. Nr.: 73543-67-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

9S-HODE (12.5-25 μM; 12-72 h) significantly downregulates the expression of miR-361-3p in HL-60 cells^[1].
9S-HODE (25 μM; 0-72 h) inhibits the viability of HL-60 cells and induces apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

human acute myeloid leukemia HL-60 cells
Concentration:

25 μM
Incubation Time:

12, 24, 36, 48, 72 h
Result:

Downregulated miR-361-3p expression in a time-dependent manner.
Increased BTG2 mRNA expression.

Apoptosis Analysis^[1]

Cell Line:

human acute myeloid leukemia HL-60 cells
Concentration:

25 μM
Incubation Time:

48 h
Result:

Increased the percentages of early apoptotic (Annexin V+/PI-) and late apoptotic (Annexin V+/PI+) HL-60 cells compared to control.

Chemical Information

CAS. Nr. 73543-67-6
Appearance Liquid
Molecular Weight 296.44
Formel C₁₈H₃₂O₃
Color Colorless to light yellow
SMILES

CCCCC/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O
Synonyms

Alpha-dimorphecolic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Solution, -20°C, 2 years

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (544 KB)
- English - EN (544 KB)
- Français - FR (544 KB)
- Deutsch - DE (544 KB)
- Norwegian - NO (544 KB)
- Español - ES (544 KB)
- Swedish - SV (544 KB)
- Italian - IT (544 KB)
- Korean - KR (544 KB)
- Portuguese - PT (544 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu S, et al. Linoleic acid derivatives target miR‐361‐3p/BTG2 to confer anticancer effects in acute myeloid leukemia. Journal of Biochemical and Molecular Toxicology, 2023, 37(11): e23481.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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9(S)-HODE

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

9(S)-HODE Related Classifications

HY-113455 Related Classifications