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Art. -Nr.: HY-15873

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FTI 276

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC₅₀s of 0.9 and 0.5 nM for Plasmodium falciparum and human.

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CAS. Nr.: 170006-72-1
Formel: C₂₁H₂₇N₃O₃S₂
Molecular Weight:433.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

FTI 276 Chemical Structure

CAS. Nr.: 170006-72-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC₅₀s of 0.9 and 0.5 nM for Plasmodium falciparum and human.

IC₅₀ & Target

IC50: 0.9 and 0.5 nM for Plasmodium falciparum and human^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	>10000 nM Compound: Hamilton FTI	Inhibition of human adenocarcinoma cell line Caco-2 proliferation Inhibition of human adenocarcinoma cell line Caco-2 proliferation	[PMID: 11784156]
LoVo	IC₅₀	50 nM Compound: Hamilton FTI	Inhibition of human adenocarcinoma cell line LoVo proliferation Inhibition of human adenocarcinoma cell line LoVo proliferation	[PMID: 11784156]
NIH3T3	EC₅₀	1 μM Compound: 1	Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells	[PMID: 10201832]
NIH3T3	IC₅₀	1 μM Compound: 1 (FTI-276)	Inhibition of mammalian H-Ras processing in NIH 3T3 cells Inhibition of mammalian H-Ras processing in NIH 3T3 cells	[PMID: 11277514]
NIH3T3	ED₅₀	>25 μM Compound: FTI-276	Effective dose against murine 3T3 fibroblasts cells Effective dose against murine 3T3 fibroblasts cells	[PMID: 14711313]
NIH3T3	ED₅₀	1 μM Compound: 1	Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells. Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells.	[PMID: 9784104]

Chemical Information

CAS. Nr. 170006-72-1
Molecular Weight 433.59
Formel C₂₁H₂₇N₃O₃S₂
SMILES

O=C(O)[C@@H](NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O)CCSC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chakrabarti D, et al. Protein farnesyltransferase and protein prenylation in Plasmodium falciparum.J Biol Chem. 2002 Nov 1; 277(44):42066-73. Epub 2002 Aug 22. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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