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Art. -Nr.: HY-12585

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AM-4668

AM-4668 is a GPR40 agonist for type 2 diabetes. EC₅₀s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively.

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Reinheit: 99.0%
CAS. Nr.: 1011531-27-3
Formel: C₂₄H₁₉F₃N₂O₄S
Molecular Weight:488.48

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

AM-4668 Chemical Structure

CAS. Nr.: 1011531-27-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

AM-4668 is a GPR40 agonist for type 2 diabetes. EC₅₀s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively^[1].

IC₅₀ & Target

EC50: 3.6 nM (GPR40, in A9 cells), 36 nM (GPR40, in CHO cells)^[1]

Alle Free Fatty Acid Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A9	EC₅₀	3.6 nM Compound: 10, AM-4668	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	[PMID: 24900872]
CHO	EC₅₀	36 nM Compound: 10, AM-4668	Agonist activity at human GPR40 expressed in CHO cells by aequorin assay Agonist activity at human GPR40 expressed in CHO cells by aequorin assay	[PMID: 24900872]

Chemical Information

CAS. Nr. 1011531-27-3
Appearance Solid
Molecular Weight 488.48
Formel C₂₄H₁₉F₃N₂O₄S
Color White to off-white
SMILES

OC(C[C@H](C1=NOC=C1)C(C=C2)=CC=C2OCC(S3)=C(C)N=C3C4=CC=C(C(F)(F)F)C=C4)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu JJ, et al. Optimization of GPR40 Agonists for Type 2 Diabetes. ACS Med Chem Lett. 2014 Feb 6;5(5):517-21. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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AM-4668

Fasiglifam

DC260126

AMG 837 calcium hydrate

TUG-770

GPR40 Activator 2

AMG 837

GPR40 Activator 1

GW-1100

Fasiglifam (Standard)

DC260126 (Standard)

AMG 837 sodium salt

AP5

Alle Free Fatty Acid Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bioz

AM-4668

Fasiglifam

DC260126

AMG 837 calcium hydrate

TUG-770

GPR40 Activator 2

AMG 837

GPR40 Activator 1

GW-1100

Fasiglifam (Standard)

DC260126 (Standard)

AMG 837 sodium salt

AP5

Alle Free Fatty Acid Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AM-4668 Related Classifications

HY-12585 Related Classifications

Bioz