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Amlitelimab

(Synonyms: KY1005; SAR445229)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Amlitelimab () is an anti-OX40 Ligand (OX40L) monoclonal antibody (mAb). Amlitelimab inhibits OX40-OX40L interaction, and can be used in the research of atopic dermatitis.

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  • Reinheit: 99%
  • CAS. Nr.: 2378692-15-8
  • Molecular Weight:145.94 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Amlitelimab
  • Experimental Validation Results for Amlitelimab
  • Experimental Validation Results for Amlitelimab
  • Experimental Validation Results for Amlitelimab
  • Amlitelimab Chemical Structure
  • Experimental Validation Results for Amlitelimab
  • Experimental Validation Results for Amlitelimab
  • Experimental Validation Results for Amlitelimab
  • Experimental Validation Results for Amlitelimab
  • Amlitelimab Chemical Structure
    Amlitelimab Chemical Structure
CAS. Nr.: 2378692-15-8
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Flow cytometric analysis of 1X10^6 Jurkat cells labeling Amlitelimab (HY-P99434, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Human OX40 Ligand/TNFSF4 Protein (ECD, mFc Tag) can bind Amlitelimab. The EC50 for this effect is 3.87 ng/mL.

  • 1/16

    Loaded Amlitelimab on AHC2 biosensor, can bind OX40 Ligand/TNFSF4 (HEK293, His, HY-P70622) with an affinity constant of <1.000E-11 M as determined in BLI assay.

  • Amlitelimab Chemical Structure
    1/16
  • Amlitelimab
  • Flow cytometric analysis of 1X10^6 Jurkat cells labeling Amlitelimab (HY-P99434, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Human OX40 Ligand/TNFSF4 Protein (ECD, mFc Tag) can bind Amlitelimab. The EC50 for this effect is 3.87 ng/mL.
  • Loaded Amlitelimab on AHC2 biosensor, can bind OX40 Ligand/TNFSF4 (HEK293, His, HY-P70622) with an affinity constant of <1.000E-11 M as determined in BLI assay.