country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-10364

Copy Link Print Information

AP24163

AP24163 is a BCR-ABL kinase inhibitor. AP24163 inhibits wild-type (native) BCR-ABL and BCR-ABL-T315I with IC₅₀ values of 7 nM and 511 nM, respectively. AP24163 can be used in the research of chronic myeloid leukemia (CML).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 926922-16-9
Formel: C₂₉H₂₅F₃N₈O
Molecular Weight:558.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

AP24163 Chemical Structure

CAS. Nr.: 926922-16-9

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Bcr-Abl Isoform-spezifische Produkte anzeigen :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	24 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	42 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	422 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	422 nM Compound: la	Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	44 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	63 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	64 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	6455 μM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	7.3 nM Compound: la	Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	7.3 μM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay	[PMID: 19572547]
K562	IC₅₀	4.3 μM Compound: 14a, AP24163	Antiproliferative activity against human K562 cells after 3 days by MTS assay Antiproliferative activity against human K562 cells after 3 days by MTS assay	[PMID: 19572547]

Chemical Information

CAS. Nr. 926922-16-9
Molecular Weight 558.56
Formel C₂₉H₂₅F₃N₈O
SMILES

O=C(NC1=CC(N2C=NC(C)=C2)=CC(C(F)(F)F)=C1)C3=CC(/C=C/N4C5=NC=NC(NC6CC6)=C5N=C4)=C(C)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (240 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen