Apoptosis inducer 46
Apoptosis inducer 46 is an apoptosis inducer. Apoptosis inducer 46 exhibits potent and selective growth inhibitory effects on metastatic triple-negative breast cancer (TNBC) cells. Apoptosis inducer 46 induces G2/M phase cell cycle arrest and apoptotic cell death in MDA-MB-231 cells, and blocks NF-κB nuclear translocation. Apoptosis inducer 46 can be used for the study of TNBC.
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- CAS. Nr.: 3085356-41-5
- Formel: C24H25NO3
- Molecular Weight:375.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
Apoptosis inducer 46 (Compound 5d) (96 h) exhibits potent growth inhibitory effects on metastatic triple-negative breast cancer (TNBC) MDA-MB-231, HCC 1806, MCF-7, BEAS 2B cells with IC50s of 0.38 μM, 0.31 μM, 0.39 μM, 0.7 μM, respectively[1].
Apoptosis inducer 46 (5-40 μM, 2-4 h) significantly reduces proteasome activity in MDA-MB-231 cells with an IC50 of 37.0 μM for proteasome inhibition, and induces accumulation of ubiquitinated proteins[1].
Apoptosis inducer 46 (5 μM, 24-72 h) increases the apoptosis rate and causes progressive accumulation of MDA-MB-231 cells in the G2/M phase of the cell cycle[1].
Apoptosis inducer 46 (5-20 μM) stabilizes cyclin D1, p53, and p21 proteins, prevents degradation of IκBα, IκBε, and IκKγ, and inhibits nuclear translocation of NF-κB in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:5 μM
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Incubation Time:24, 48, 72 h
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Result:Increased the apoptosis rate of MDA-MB-231 cells.
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Cell Line:MDA-MB-231 cells
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Concentration:5 μM
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Incubation Time:24, 48, 72 h
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Result:Caused progressive accumulation of MDA-MB-231 cells in the G2/M phase of the cell cycle.
- Cytoplasmic-Nuclear Fractionated Protein Extraction
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Flow cytometric DNA-content cell-cycle staining
- Cell Cytotoxicity Assay
- Mammalian live/dead viability and cytotoxicity staining
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Apoptosis Solutions
- Protocol for Cell Cycle
- Research Protocol for Inflammation-related Diseases
- Breast Cancer Modeling
Chemical Information
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CAS. Nr. 3085356-41-5
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Molecular Weight 375.46
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Formel C24H25NO3
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SMILES
OC1=C(C=C(C=C1)/C=C2CN(C3CC3)C/C(C\2=O)=C\C4=CC=C(C=C4)C)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Apoptosis inducer 46 Related Classifications
HY-178132 Related Classifications
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