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Art. -Nr.: HY-15379

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Atevirdine

Kundenbewertung

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Atevirdine is a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Atevirdine inhibits non-nucleoside reverse transcriptase that leads to viral multiplication.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.69%
CAS. Nr.: 136816-75-6
Formel: C₂₁H₂₅N₅O₂
Molecular Weight:379.46

Speicherung:

-80°C

Atevirdine Chemical Structure

CAS. Nr.: 136816-75-6

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Verfügbarkeit

Menge

Amount: USD 0.00

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Atevirdine is a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Atevirdine inhibits non-nucleoside reverse transcriptase that leads to viral multiplication^[1].

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC₅₀	10 x 10^-4 μM Compound: Atevirdine	Antiviral activity against HIV infected in human CEM-SS cells assessed as inhibition of virus induced cell killing by XTT assay Antiviral activity against HIV infected in human CEM-SS cells assessed as inhibition of virus induced cell killing by XTT assay	[PMID: 19345581]
MT2	CC₅₀	>10 μM Compound: 2	Cytotoxic concentration against MT-2 cells Cytotoxic concentration against MT-2 cells	[PMID: 7684450]
MT2	ED₅₀	<0.2 μM Compound: 2	Inhibition of HIV-1 IIIB replication in MT2 (human lymphocyte) cells. Inhibition of HIV-1 IIIB replication in MT2 (human lymphocyte) cells.	[PMID: 7684450]
MT2	IC₅₀	1.59 μM Compound: U-87201	Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells	[PMID: 7689109]
PBMC	CC₅₀	>10 μM Compound: 2	Cytotoxic concentration against PBMC cells Cytotoxic concentration against PBMC cells	[PMID: 7684450]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 136816-75-6
Appearance Solid
Molecular Weight 379.46
Formel C₂₁H₂₅N₅O₂
Color White to light yellow
SMILES

O=C(N1CCN(C2=NC=CC=C2NCC)CC1)C(N3)=CC4=C3C=CC(OC)=C4
Versand

Shipping with dry ice.
Speicherung

-80°C

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (329.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6353 mL

13.1766 mL

26.3532 mL

5 mM

0.5271 mL

2.6353 mL

5.2706 mL

10 mM

0.2635 mL

1.3177 mL

2.6353 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Been-Tiktak AM, et, al. Safety, tolerance, and efficacy of atevirdine in asymptomatic human immunodeficiency virus-infected individuals. Antimicrob Agents Chemother. 1996 Nov;40(11):2664-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6353 mL	13.1766 mL	26.3532 mL	65.8831 mL
	5 mM	0.5271 mL	2.6353 mL	5.2706 mL	13.1766 mL
	10 mM	0.2635 mL	1.3177 mL	2.6353 mL	6.5883 mL
	15 mM	0.1757 mL	0.8784 mL	1.7569 mL	4.3922 mL
	20 mM	0.1318 mL	0.6588 mL	1.3177 mL	3.2942 mL
	25 mM	0.1054 mL	0.5271 mL	1.0541 mL	2.6353 mL
	30 mM	0.0878 mL	0.4392 mL	0.8784 mL	2.1961 mL
	40 mM	0.0659 mL	0.3294 mL	0.6588 mL	1.6471 mL
	50 mM	0.0527 mL	0.2635 mL	0.5271 mL	1.3177 mL
	60 mM	0.0439 mL	0.2196 mL	0.4392 mL	1.0981 mL
	80 mM	0.0329 mL	0.1647 mL	0.3294 mL	0.8235 mL
	100 mM	0.0264 mL	0.1318 mL	0.2635 mL	0.6588 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Atevirdine

Anti-Infection Compound Library

Clinical Compound Library

Antiviral Compound Library

Drug Repurposing Compound Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Atevirdine

Anti-Infection Compound Library

Clinical Compound Library

Antiviral Compound Library

Drug Repurposing Compound Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Atevirdine Related Classifications

HY-15379 Related Classifications