Bfl-1-IN-3
Based on 1 publication(s) in Google Scholar
Bfl-1-IN-3 (Compound 56) is a selective, competitive inhibitor for Bfl-1 on BID binding site with Ki of 105 nM. Bfl-1-IN-3 inhibits the proliferation of cell pfeiffer and MV4-11, with IC50 of 6.92 μM and 12.6 μM. Bfl-1-IN-3 induces apoptosis in pfeiffer cells. Bfl-1-IN-3 overcomes Venetoclax (HY-15531) resistance at the cellular level, and shows synergistically enhanced anti-tumor activity with Venetoclax.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C40H38ClN5O4
- Molecular Weight:688.21
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Bfl-1-IN-3
More
Biologische Aktivität
Beschreibung
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
12.6 μM
Compound: 56; LJE119
|
Antiproliferative activity against human MV4-11 cells expressing high BCL-2 assessed as cell viability measured after 72 hrs by Cell Counting Kit-8 assay
Antiproliferative activity against human MV4-11 cells expressing high BCL-2 assessed as cell viability measured after 72 hrs by Cell Counting Kit-8 assay
|
[PMID: 38913996] |
| Pfeiffer | IC50 |
6.92 μM
Compound: 56; LJE119
|
Antiproliferative activity against human Pfeiffer cells expressing high BCL-2/BFL-1 assessed as cell viability measured after 72 hrs by Cell Counting Kit-8 assay
Antiproliferative activity against human Pfeiffer cells expressing high BCL-2/BFL-1 assessed as cell viability measured after 72 hrs by Cell Counting Kit-8 assay
|
[PMID: 38913996] |
Chemical Information
-
Molecular Weight 688.21
-
Formel C40H38ClN5O4
-
SMILES
ClC1=CC(CC)=C(C2=C(CN3CCN(C4=CC(OC5=CC(C=CN6)=C6N=C5)=C(C(O)=O)C=C4)CC3)CCC7=CC(NC(C=C)=O)=CC=C27)C=C1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Bfl-1-IN-3 Related Classifications
HY-162642 Related Classifications
Powered by Bioz