BPIQ-I
BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively.
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- CAS. Nr.: 174709-30-9
- Formel: C16H12BrN5
- Molecular Weight:354.20
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
0.025 nM
Compound: 12
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Inhibition of tyrosine kinase activity of Epidermal growth factor receptor from human A431 carcinoma cells
Inhibition of tyrosine kinase activity of Epidermal growth factor receptor from human A431 carcinoma cells
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[PMID: 8632415] |
BPIQ-I (0-50 µM; 3 days) shows antiproliferative activity with EC50s of >50, 30, >50, 6.5, >50 µM for A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells, respectively[1].
BPIQ-I (10 nM) blocks erbB RTKs by competing with ATP, eliminating the CO2 sensitivity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells
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Concentration:0-50 µM
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Incubation Time:3 days
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Result:Inhibited cells growth with EC50s of >50, 30, >50, 6.5, >50 µM for A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells, respectively.
Chemical Information
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CAS. Nr. 174709-30-9
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Molecular Weight 354.20
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Formel C16H12BrN5
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SMILES
CN1C=NC2=CC3=C(NC4=CC=CC(Br)=C4)N=CN=C3C=C21
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Synonyms
PD 159121
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Rae JM, et al. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Res Treat. 2004 Jan;83(2):99-107. [Content Brief]
[2]. Zhou Y, et al. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. Am J Physiol Renal Physiol. 2006 Aug;291(2):F358-67. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BPIQ-I Related Classifications
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