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Art. -Nr.: HY-183960

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BPyO-34

BPyO-34 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC₅₀ of 0.52 μM against human targets. BPyO-34 inhibits the activity of ASK1 in in vitro kinase assays. BPyO-34 can be used in research related to various diseases such as diabetes and cancer.

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CAS. Nr.: 890601-68-0
Formel: C₃₂H₂₉FN₂O₅S
Molecular Weight:572.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

BPyO-34 Chemical Structure

CAS. Nr.: 890601-68-0

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

BPyO-34 inhibits recombinant human ASK1 catalytic subunit with an IC₅₀ of 0.52 μM in an in vitro biochemical kinase assay^[1].
BPyO-34 (10 μM) shows preferential inhibition of recombinant human ASK1 over recombinant human CK2, FGFR1, Tie2, JNK3, and Aurora A^[1].
BPyO-34 binds to the ATP-binding pocket of human ASK1 via specific hydrogen bonding, hydrophobic, and sulfur-π interactions with key amino acid residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 890601-68-0
Molecular Weight 572.65
Formel C₃₂H₂₉FN₂O₅S
SMILES

O=C(C1=C(C(N(C1C2=CC(OCCC(C)C)=CC=C2)C3=NC4=C(S3)C=C(F)C=C4)=O)O)C5=CC=C6OC(CC6=C5)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Starosyla SA, et al. Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one. Bioorg Med Chem. 2015;23(10):2489-2497. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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