BRD4 D1-IN-2
BRD4 D1-IN-2 (compound 26) is a potent and selective BRD4 D1 inhibitor (IC50<0.092 µM). BRD4 D1-IN-2 has 15 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC.
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- CAS. Nr.: 2863687-22-1
- Formel: C33H39F3N6O
- Molecular Weight:592.70
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
BRD4 BD1 <0.092 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| A549 | EC50 |
3.6 μM
Compound: 26
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Cytotoxicity against human A549 cells assessed as viable cells incubated for 23 hrs by alamar blue assay
Cytotoxicity against human A549 cells assessed as viable cells incubated for 23 hrs by alamar blue assay
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[PMID: 35007061] |
Chemical Information
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CAS. Nr. 2863687-22-1
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Molecular Weight 592.70
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Formel C33H39F3N6O
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SMILES
CC(C1=CC=C(C(OC2=NC(C3=C(N=CN3C4CCN(CC4)CCN(C)C)C5=CC=C(C=C5)C(F)(F)F)=CC=N2)=C1)C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BRD4 D1-IN-2 Related Classifications
HY-142705 Related Classifications
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