BW A4C
BW A4C is a selective 5-lipoxygenase (5-LO) inhibitor. BW A4C is also an inhibitor of linoleic acid 8R-dioxygenase in Gaeumannomyces graminis, with an IC50 value of 0.2 μM. BW A4C can be used in research on diseases such as asthma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 106328-57-8
- Formel: C17H17NO3
- Molecular Weight:283.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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5-LO |
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Cell Line
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Type | Value | Description | References |
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| PMNL | IC50 |
0.05 μM
Compound: BWA4C
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Inhibition of 5-lipoxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis
Inhibition of 5-lipoxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis
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[PMID: 22551629] |
| PMNL | IC50 |
0.11 μM
Compound: 8, BW-A4C
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Inhibition of 5-LO in PMNL cells
Inhibition of 5-LO in PMNL cells
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[PMID: 19053751] |
| RBL-1 | IC50 |
100 nM
Compound: 4 (BW-A4C)
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Compound was tested for in vitro inhibition on broken human PMNL
Compound was tested for in vitro inhibition on broken human PMNL
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[PMID: 8709092] |
| U-937 | IC50 |
>30 μM
Compound: BWA4C
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Cytotoxicity against human U937 cells assessed as cell viability after 48 hrs by WST-1 assay
Cytotoxicity against human U937 cells assessed as cell viability after 48 hrs by WST-1 assay
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[PMID: 22551629] |
Chemical Information
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CAS. Nr. 106328-57-8
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Molecular Weight 283.32
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Formel C17H17NO3
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SMILES
CC(N(O)C/C=C/C1=CC=CC(OC2=CC=CC=C2)=C1)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Payne AN, et al. Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99. [Content Brief]
[2]. Brodowsky ID, et al. BW A4C and other hydroxamic acids are potent inhibitors of linoleic acid 8R-dioxygenase of the fungus Gaeumannomyces graminis. Eur J Pharmacol. 1994 Mar 11;254(1-2):43-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BW A4C Related Classifications
HY-136923 Related Classifications
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