CCKBR agonist-2
Based on 1 Customer Validation
CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimer's disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function.
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- Reinheit : 99.81%
- CAS. Nr.: 923714-61-8
- Formel: C15H15NO4
- Molecular Weight:273.28
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 923714-61-8
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Appearance Solid
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Molecular Weight 273.28
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Formel C15H15NO4
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Color White to off-white
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SMILES
COC1=CC(OC)=CC(C(NC2=C(C=CC=C2)O)=O)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (365.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6593 mL | 18.2963 mL | 36.5925 mL | 91.4813 mL |
| 5 mM | 0.7319 mL | 3.6593 mL | 7.3185 mL | 18.2963 mL | |
| 10 mM | 0.3659 mL | 1.8296 mL | 3.6593 mL | 9.1481 mL | |
| 15 mM | 0.2440 mL | 1.2198 mL | 2.4395 mL | 6.0988 mL | |
| 20 mM | 0.1830 mL | 0.9148 mL | 1.8296 mL | 4.5741 mL | |
| 25 mM | 0.1464 mL | 0.7319 mL | 1.4637 mL | 3.6593 mL | |
| 30 mM | 0.1220 mL | 0.6099 mL | 1.2198 mL | 3.0494 mL | |
| 40 mM | 0.0915 mL | 0.4574 mL | 0.9148 mL | 2.2870 mL | |
| 50 mM | 0.0732 mL | 0.3659 mL | 0.7319 mL | 1.8296 mL | |
| 60 mM | 0.0610 mL | 0.3049 mL | 0.6099 mL | 1.5247 mL | |
| 80 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1435 mL | |
| 100 mM | 0.0366 mL | 0.1830 mL | 0.3659 mL | 0.9148 mL |
CCKBR agonist-2 Related Classifications
HY-179721 Related Classifications
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