CH5447240
CH5447240 is an agonist for parathyroid hormone receptor 1 (PTHR1), that inhibits human PTHR1 with an EC50 of 12 μM. CH5447240 exhibits good metabolic stability in human liver microsomes. CH5447240 increases serum calcium levels in rats. CH5447240 can be used in research about hypoparathyroidism.
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- CAS. Nr.: 1253919-92-4
- Formel: C26H39N5O4S
- Molecular Weight:517.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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PTH1R 12 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LLC-PK1 | EC50 |
12 μM
Compound: 1; CH5447240
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Agonist activity at recombinant human PTHR1 expressed in pig LLC-PK1 cells assessed as increase in cAMP production measured after 20 mins by EIA
Agonist activity at recombinant human PTHR1 expressed in pig LLC-PK1 cells assessed as increase in cAMP production measured after 20 mins by EIA
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[PMID: 32022560] |
Chemical Information
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CAS. Nr. 1253919-92-4
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Molecular Weight 517.68
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Formel C26H39N5O4S
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SMILES
O=C(N)N(C1=CC(C)=C(CCS(=O)(N(CC2)CCC2(NC([C@H]3CC[C@H](C)CC3)=N4)C4=O)=O)C(C)=C1)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CH5447240 Related Classifications
HY-120398 Related Classifications
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