CHVB-032

CHVB-032 potently and selectively inhibits the replication of CHIKV 899 in Vero cells, with an EC₅₀ of 2.7 µM and a CC₅₀ greater than 75 µM^[1].
CHVB-032 inhibits viral RNA replication of various CHIKV isolates in Vero cells, with EC₅₀ values ranging from 1.2 to 7.3 µM, but shows no activity against other tested alphaviruses^[1].
CHVB-032 (50-1000 µM; 30 min) completely inhibits both MTase and GTase activities of purified wild-type SFV nsP1 at concentrations ranging from 50 to 1000 µM^[1].
CHVB-032 potently inhibits the replication of CHIKV-899 in Vero cells, with an EC₅₀ of 2.7 μM and a CC₅₀ greater than 75 μM^[2].
CHVB-032 (0.63-20.00 μM) reduces viral RNA levels of CHIKV-899 and production of infectious progeny viruses in Vero cells in a dose-dependent manner in vitro, with a reduction of over 4-log₁₀ at the highest tested concentration^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.