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Art. -Nr.: HY-123312

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CK-548

Name: CK-548
Brand: MedChemExpress
SKU: HY-123312
Price: 160.00 USD
Availability: PreOrder

(Synonyms: CK-0993548)

CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC₅₀ of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection.

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CAS. Nr.: 388604-55-5
Formel: C₁₅H₁₁BrClNO₂S
Molecular Weight:384.68

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CK-548 Chemical Structure

CAS. Nr.: 388604-55-5

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Fluorescent Dye

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC₅₀ of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection^[1]^[2].

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	9.95 μM Compound: 1, CK-548	Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay	[PMID: 24794770]
MDA-MB-231	IC₅₀	26.98 μM Compound: 1, CK-548	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay	[PMID: 24794770]

Chemical Information

CAS. Nr. 388604-55-5
Appearance Solid
Molecular Weight 384.68
Formel C₁₅H₁₁BrClNO₂S
Color White to off-white
SMILES

O=C1N(C(SC1)C2=CC=CC(Br)=C2)C3=CC(Cl)=CC=C3O
Synonyms

CK-0993548
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (596 KB)
- English - EN (596 KB)
- Français - FR (596 KB)
- Deutsch - DE (596 KB)
- Norwegian - NO (596 KB)
- Español - ES (596 KB)
- Swedish - SV (596 KB)
- Italian - IT (596 KB)
- Korean - KR (596 KB)
- Portuguese - PT (596 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. B. J. Nolen, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature.

[2]. Spear M, et al. HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J Biol Chem. 2014;289(10):6949-6959. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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CK-548

Alle HIV Isoform-spezifische Produkte anzeigen