CQ211
Based on 1 Customer Validation
CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines.
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- Reinheit: 99.90%
- CAS. Nr.: 2648986-65-4
- Formel: C26H22F3N7O2
- Molecular Weight:521.49
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Speicherung:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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RIOK2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
0.38 μM
Compound: 7m ; CQ211
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Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
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[PMID: 35584513] |
| MKN-1 | IC50 |
0.61 μM
Compound: 7m ; CQ211
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Antiproliferative activity against human MKN-1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MKN-1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
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[PMID: 35584513] |
| MKN-1 | IC50 |
1.69 μM
Compound: 7; CQ211
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Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay
Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay
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[PMID: 37859717] |
| MOLT-4 | IC50 |
2.12 μM
Compound: 7; CQ211
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Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay
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[PMID: 37859717] |
| U-87MG ATCC | IC50 |
1.65 μM
Compound: 7; CQ211
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Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay
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[PMID: 37859717] |
CQ211 (0-5.0 μM; 4 h) suppresses the phosphorylation of mTOR in cancer cells[1].
CQ211 can obviously suppress the proliferation of MKN-1 and HT-29 cells with IC50 values of 0.61 μM and 0.38 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MKN-1 and HT-29 cells
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Concentration:0, 0.3, 0.6, 1.2, 2.5, and 5.0 μM
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Incubation Time:4 h
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Result:Suppresseed the phosphorylation of mTOR in cancer cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CB17-SCID mice (6-8 weeks of age) injected wtih MKN-1 cells[1]
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Dosage:25 mg/kg
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Administration:Intraperitoneal administration; for 18 consecutive days; once daily
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Result:Inhibited the tumor progression with tumor growth inhibition (TGI) of 30.9%.
Chemical Information
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CAS. Nr. 2648986-65-4
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Appearance Solid
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Molecular Weight 521.49
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Formel C26H22F3N7O2
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Color Off-white to light yellow
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SMILES
O=C1C2=C(C3=CC(C4=CC=C(N=C4)OC)=CC=C3N1)N(N=N2)C5=CC=C(C(C(F)(F)F)=C5)N6CCNCC6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Lösungsmittel & Löslichkeit
DMSO : 12.5 mg/mL (23.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9176 mL | 9.5879 mL | 19.1758 mL | 47.9396 mL |
| 5 mM | 0.3835 mL | 1.9176 mL | 3.8352 mL | 9.5879 mL | |
| 10 mM | 0.1918 mL | 0.9588 mL | 1.9176 mL | 4.7940 mL | |
| 15 mM | 0.1278 mL | 0.6392 mL | 1.2784 mL | 3.1960 mL | |
| 20 mM | 0.0959 mL | 0.4794 mL | 0.9588 mL | 2.3970 mL |
CQ211 Related Classifications
HY-147655 Related Classifications
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