Cymserine
Cymserine is a blood-brain barrier-permeable butyrylcholinesterase (BuChE) inhibitor with an IC50 value of 56.43 nM and a Ki of 38 nM. Cymserine binds to the catalytic domain of BuChE in a concentration-dependent manner to form a stable carbamylated enzyme complex, and exhibits BuChE selectivity over acetylcholinesterase due to its structural compatibility with the larger acyl-binding pocket of BuChE. Cymserine can be used in the research of Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 145209-39-8
- Formel: C23H29N3O2
- Molecular Weight:379.50
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
BuChE 38 nM (Ki) |
Cymserine (0.02-0.12 μM; 0-60 min) potently inhibits purified human BuChE with an IC50 range of 63-100 nM (depending on substrate concentration), a minimum IC50 of 56.43 nM, and a Ki of 38 nM, and exhibits time-dependent binding activity loss with a critical 50% activity loss time of 7.54 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 145209-39-8
-
Molecular Weight 379.50
-
Formel C23H29N3O2
-
SMILES
C[C@]12C3=CC(OC(NC4=CC=C(C=C4)C(C)C)=O)=CC=C3N([C@@]1([H])N(CC2)C)C
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cymserine Related Classifications
HY-182615 Related Classifications
Powered by Bioz