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Art. -Nr.: HY-188015

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DBCO-PEG4-GGFG-Triptolide

DBCO-PEG4-GGFG-Triptolide is a triptolide-based antibody-drug conjugate (ADC) payload, consisting of a DBCO click chemistry reactive group, a PEG4 linker, a cathepsin-cleavable GGFG peptide segment, and triptolide. DBCO-PEG4-GGFG-Triptolide binds to antibodies via glycosylation conjugation, releases active triptolide intracellularly to exert cytotoxic effects, and is commonly used in combination with camptothecin-class toxins (Exatecan (HY-13631) / DXd (HY-13631D)) for the preparation of dual-toxin ADCs.

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CAS. Nr.: 3086791-85-4
Formel: C₆₈H₈₁N₇O₁₉
Molecular Weight:1300.41

Speicherung:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

DBCO-PEG4-GGFG-Triptolide Chemical Structure

CAS. Nr.: 3086791-85-4

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Menge

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle ADC Payloads Isoform-spezifische Produkte anzeigen :

In Vitro

ADC is a targeted biologic composed of a monoclonal antibody that targets a specific antigen, a cleavable or non-cleavable linker, and a highly active cytotoxic payload (small-molecule drug). It precisely delivers the payload into tumor cells via the antibody to achieve highly effective and low-toxicity killing effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 3086791-85-4
Appearance Solid
Molecular Weight 1300.41
Formel C₆₈H₈₁N₇O₁₉
Color White to off-white
SMILES

C[C@@]12[C@@]34[C@@]5([C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5)[C@@H]([C@@]7([C@](O7)([H])[C@]3([H])O4)C(C)C)OC(COCNC(CNC([C@H](CC8=CC=CC=C8)NC(CNC(CNC(CCOCCOCCOCCOCCNC(CCC(N9CC%10=CC=CC=C%10C#CC%11=CC=CC=C%119)=O)=O)=O)=O)=O)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (38.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7690 mL

3.8449 mL

7.6899 mL

5 mM

0.1538 mL

0.7690 mL

1.5380 mL

10 mM

0.0769 mL

0.3845 mL

0.7690 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ke X, et al. Double-toxin antibody-drug conjugate and use thereof. International Patent Application No. WO 2025/103474 A1. Published May 22, 2025.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.7690 mL	3.8449 mL	7.6899 mL	19.2247 mL
	5 mM	0.1538 mL	0.7690 mL	1.5380 mL	3.8449 mL
	10 mM	0.0769 mL	0.3845 mL	0.7690 mL	1.9225 mL
	15 mM	0.0513 mL	0.2563 mL	0.5127 mL	1.2816 mL
	20 mM	0.0384 mL	0.1922 mL	0.3845 mL	0.9612 mL
	25 mM	0.0308 mL	0.1538 mL	0.3076 mL	0.7690 mL
	30 mM	0.0256 mL	0.1282 mL	0.2563 mL	0.6408 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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DBCO-PEG4-GGFG-Triptolide

Alle ADC Payloads Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

In Vitro

Chemical Information

Lösungsmittel & Löslichkeit

In Vitro:

In Vivo Dissolution Calculator

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DBCO-PEG4-GGFG-Triptolide Related Classifications

HY-188015 Related Classifications

Bioz

Keywords

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