Art. -Nr.: HY-149132

Dendrogenin A

(Synonyms: DDA)

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Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC₅₀ of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase.

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Reinheit: 96.7%
CAS. Nr.: 1191043-85-2
Formel: C₃₂H₅₅N₃O₂
Molecular Weight:513.80

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Dendrogenin A Chemical Structure

CAS. Nr.: 1191043-85-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.56 μM Compound: 14, Dendrogenin A	Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
B16-F10	IC₅₀	0.68 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
HCT-8	IC₅₀	0.89 μM Compound: 14, Dendrogenin A	Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
KG-1	IC₅₀	5.53 μM Compound: 14, Dendrogenin A	Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
MCF7	IC₅₀	2.31 μM Compound: 14, Dendrogenin A	Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
N2a	IC₅₀	2.32 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
NB-4	IC₅₀	1.32 μM Compound: 14, Dendrogenin A	Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
P19	IC₅₀	1.8 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
P19	IC₅₀	2.4 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay	[PMID: 19821610]
SH-SY5Y	IC₅₀	1.35 μM Compound: 14, Dendrogenin A	Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
SK-MEL-28	IC₅₀	2.12 μM Compound: 14, Dendrogenin A	Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
SK-N-SH	IC₅₀	2.24 μM Compound: 14, Dendrogenin A	Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
SW-620	IC₅₀	0.42 μM Compound: 14, Dendrogenin A	Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
TS/A	IC₅₀	1.28 μM Compound: 14, Dendrogenin A	Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
U-87MG ATCC	IC₅₀	0.74 μM Compound: 14, Dendrogenin A	Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
U-937	IC₅₀	0.79 μM Compound: 14, Dendrogenin A	Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay	[PMID: 19821610]
U-937	IC₅₀	0.8 μM Compound: 14, Dendrogenin A	Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay	[PMID: 19821610]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 1191043-85-2
Appearance Solid
Molecular Weight 513.80
Formel C₃₂H₅₅N₃O₂
Color White to off-white
SMILES

C[C@@]12[C@]3([H])[C@](C[C@H]([C@]1(C[C@H](CC2)O)O)NCCC4=CN=CN4)([H])[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)CCCC(C)C)C
Synonyms

DDA
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 30 mg/mL (58.39 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9463 mL

9.7314 mL

19.4628 mL

5 mM

0.3893 mL

1.9463 mL

3.8926 mL

10 mM

0.1946 mL

0.9731 mL

1.9463 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bauriaud-Mallet M, et al., The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells. J Steroid Biochem Mol Biol. 2019 Sep;192:105390. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9463 mL	9.7314 mL	19.4628 mL	48.6571 mL
	5 mM	0.3893 mL	1.9463 mL	3.8926 mL	9.7314 mL
	10 mM	0.1946 mL	0.9731 mL	1.9463 mL	4.8657 mL
	15 mM	0.1298 mL	0.6488 mL	1.2975 mL	3.2438 mL
	20 mM	0.0973 mL	0.4866 mL	0.9731 mL	2.4329 mL
	25 mM	0.0779 mL	0.3893 mL	0.7785 mL	1.9463 mL
	30 mM	0.0649 mL	0.3244 mL	0.6488 mL	1.6219 mL
	40 mM	0.0487 mL	0.2433 mL	0.4866 mL	1.2164 mL
	50 mM	0.0389 mL	0.1946 mL	0.3893 mL	0.9731 mL

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Dendrogenin A

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Dendrogenin A

Metabolism/Protease Compound Library

Natural Product Library

Anti-Cancer Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Terpenoids Library

Lipid Metabolism Compound Library

Anti-Cancer Natural Product Library

Nuclear Receptor Compound Library

Metabolic Enzyme Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Dendrogenin A Related Classifications

HY-149132 Related Classifications