Deoxythymidine-5'-triphosphate
Deoxythymidine-5'-triphosphate (dTTP) is a deoxyribonucleoside triphosphate and a thymidine analog, which serves as a direct precursor for DNA synthesis. Deoxythymidine-5'-triphosphate can be used for DNA amplification in the DNA polymerase chain reaction (PCR). Deoxythymidine-5'-triphosphate is also applicable to research related to diseases such as leukemia.
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- CAS. Nr.: 365-08-2
- Formel: C10H17N2O14P3
- Molecular Weight:482.17
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Human Endogenous Metabolite |
In Vitro
Deoxythymidine‑5'-triphosphate trisodium solution (100 mM) exhibits an average concentration of 1.4 pmol/106 cells in normal bone marrow nucleated cells, while its average concentrations in bone marrow nucleated cells corresponding to acute myeloid leukemia, chronic myeloid leukemia, and myeloproliferative disorders are 5.8 pmol/106 cells, 3.8 pmol/106 cells, and 5.9 pmol/106 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 365-08-2
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Molecular Weight 482.17
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Formel C10H17N2O14P3
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SMILES
O=C1N([C@H]2C[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)C=C(C(N1)=O)C
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Synonyms
dTTP
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Tattersall MH, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. European journal of clinical investigation. 1975 Apr;5(2):191-202. [Content Brief]
[2]. Rondan Dueñas JC, et al. Specific requirements for PCR amplification of long mitochondrial A+T-rich DNA. Biotechniques. 1999 Aug;27(2):258-60. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Deoxythymidine-5'-triphosphate Related Classifications
HY-138615 Related Classifications
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Keywords
- Deoxythymidine-5'-triphosphate
- 365-08-2
- dTTP
- DNA/RNA Synthesis
- Nucleoside Antimetabolite/Analog
- Endogenous Metabolite
- chronic granulocytic leukaemia
- acute myeloid leukaemia
- DNA synthesis
- phytohaemagglutinin-stimulated lymphocytes
- leukaemia
- antifolate agents
- nucleated marrow cells
- hydroxyurea
- 5-fluorouracil
- myeloproliferative diseases
- Inhibitor
- inhibitor
- inhibit