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Art. -Nr.: HY-182529

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DHPS-IN-3

DHPS-IN-3 (Compound 26d) is a NAD-competitive DHPS inhibitor, with an IC₅₀ of 0.0092 μM at 14 μM NAD and an IC₅₀ of 0.069 μM at 250 μM NAD. DHPS-IN-3 is applicable for cancer research.

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CAS. Nr.: 2470012-40-7
Formel: C₁₈H₂₃N₃OS
Molecular Weight:329.46

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DHPS-IN-3 Chemical Structure

CAS. Nr.: 2470012-40-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

DHPS-IN-3 potently inhibits deoxyhypusine synthase with an IC₅₀ of 0.0092 μM at 14 μM NAD, showing a NAD-competitive inhibitory profile^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	V_dss	CL_total	C_max	MRT	F
Mice^[1]	0.1 mg/kg	i.v.	8491 mL/kg	8965 mL/h/kg	/	/	/
Mice^[1]	1 mg/kg	p.o.	/	/	4.8 ng/mL	2.46 h	11.7 %

Chemical Information

CAS. Nr. 2470012-40-7
Appearance Solid
Molecular Weight 329.46
Formel C₁₈H₂₃N₃OS
Color Off-white to pink
SMILES

O=C1C2=C(CCN1[C@@H](CN)CC(C)C)C(C3=CN=CC=C3)=CS2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Tanaka Y, et al. New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. ACS Med Chem Lett. 2020;11(8):1645-1652. Published 2020 Jul 30. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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