FGFR-IN-24
FGFR-IN-24 (Compound 8r) is a FGFR inhibitor. FGFR-IN-24 potently inhibits FGFR1/2/3 with IC50 values of 10.0, 6.9, and 30.2 nM, respectively. FGFR-IN-24 exhibits superior inhibitory activity toward FGFR1V561M, FGFR2V564F, and FGFR2N549K mutations with IC50 values of 6.8, 0.7, and 0.8 nM, respectively. FGFR-IN-24 induces Apoptosis. FGFR-IN-24 efficiently suppresses the phosphorylation of FGFR2 and its downstream signaling mediators (AKT and MAPK). FGFR-IN-24 demonstrates favorable antitumor efficacy in an RT112/84 bladder cancer xenograft model.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C27H31N7O3
- Molecular Weight:501.58
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
FGFR1 10.0 nM (IC50) |
FGFR2 6.9 nM (IC50) |
FGFR3 30.2 nM (IC50) |
Chemical Information
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Molecular Weight 501.58
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Formel C27H31N7O3
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SMILES
O=C1N(CCOCCOC(C(C2=CN(N=C2)C3CCN(CC3)C)=C4)=NN5C4=NC=C5C6=CC1=CC=C6)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FGFR-IN-24 Related Classifications
HY-181031 Related Classifications
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