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CD2BP2 - CD2 cytoplasmic tail binding protein 2 Gene

Also Known as LIN1; Snu40; FWP010; U5-52K; PPP1R59

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10421

About CD2BP2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,350,773-30,355,308 (from NCBI)

This gene has 3 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in brain (RPKM 16.4), lymph node (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]

CD2BP2 Products (2)

mRNA	Protein	Name
NM_001243646.2	NP_001230575.1	CD2 antigen cytoplasmic tail-binding protein 2
NM_006110.3	NP_006101.1	CD2 antigen cytoplasmic tail-binding protein 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9843987	GOA
enables ribonucleoprotein complex binding	IDA IDA: Inferred from direct assay	15840814	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
NOT part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	15840814	GOA
part of U5 snRNP	IDA IDA: Inferred from direct assay	15840814	GOA
colocalizes with nuclear speck	IDA IDA: Inferred from direct assay	15840814	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	15840814	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15840814	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD2BP2 Protein Structure

GYF

0
100
200
300
341 a.a.

Protein Preferred Names	Protein Names
CD2 antigen cytoplasmic tail-binding protein 2	CD2 cytoplasmic domain-binding protein 2

CD2BP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CD2BP2	O95400	ZNHIT2	Homo sapiens	Q9UHR6	Validated Y2H	32296183
Intra	CD2BP2	O95400	ZNHIT2	Homo sapiens	Q9UHR6	Anti Tag CoIP	28514442
Intra	CD2BP2	O95400	AKNA	Homo sapiens	Q7Z591	Protein Array	16000308
Intra	CD2BP2	O95400	ACAD11	Homo sapiens	Q709F0	Anti Tag CoIP	28514442
Intra	CD2BP2	O95400	ACAD11	Homo sapiens	Q709F0	Y2H Prey Pooling	32296183
Intra	CD2BP2	O95400	ACAD11	Homo sapiens	Q709F0	Anti Tag CoIP	35271311
Intra	CD2BP2	O95400	ACAD11	Homo sapiens	Q709F0	Validated Y2H	32296183
Intra	CD2BP2	O95400	ACAD11	Homo sapiens	Q709F0	Anti Tag CoIP	33961781
Intra	CD2BP2	O95400	PPP1CC	Homo sapiens	P36873	Y2H Prey Pooling	25416956
Intra	CD2BP2	O95400	PPP1CA	Homo sapiens	P62136	Y2H	22365833
Intra	CD2BP2	O95400	PPP1CA	Homo sapiens	P62136	Pull Down	19389623
Intra	CD2BP2	O95400	SNRPB	Homo sapiens	P14678	Protein Array	16000308
Intra	CD2BP2	O95400	SNRPB	Homo sapiens	P14678	Pull Down	15105431
Intra	CD2BP2	O95400	SNRPB	Homo sapiens	P14678-2	Pull Down	15105431
Intra	CD2BP2	O95400	SNRPB	Homo sapiens	P14678-2	Anti Tag CoIP	28514442
Intra	CD2BP2	O95400	SNRPB	Homo sapiens	P14678-2	Validated Y2H	32296183
Intra	CD2BP2	O95400	SNRPB	Homo sapiens	P14678-2	Peptide Array	15105431
Intra	CD2BP2	O95400	SNRPB	Homo sapiens	P14678-2	Y2H Prey Pooling	25416956
Intra	CD2BP2	O95400	SNRPB	Homo sapiens	P14678-2	Y2H Array	25416956
Intra	CD2BP2	O95400	CD2	Homo sapiens	P06729	Y2H	9843987
Intra	CD2BP2	O95400	CD2	Homo sapiens	P06729	Y2H	16000308
Intra	CD2BP2	O95400	CD2	Homo sapiens	P06729	NMR	15105431
Intra	CD2BP2	O95400	CD2	Homo sapiens	P06729	Pull Down	9741631
Intra	CD2BP2	O95400	CD2	Homo sapiens	P06729	NMR	12426371
Intra	CD2BP2	O95400	CD2	Homo sapiens	P06729	Peptide Array	15105431
Intra	CD2BP2	O95400	PRPF6	Homo sapiens	O94906	Anti Tag CoIP	35271311
Intra	CD2BP2	O95400	PRPF6	Homo sapiens	O94906	Anti Tag CoIP	33961781
Intra	CD2BP2	O95400	PRPF6	Homo sapiens	O94906	Anti Bait CoIP	17353931
Intra	CD2BP2	O95400	PRPF6	Homo sapiens	O94906	Anti Tag CoIP	28514442
Intra	CD2BP2	O95400	SNRPA	Homo sapiens	P09012	Peptide Array	15105431
Intra	CD2BP2	O95400	SNRPN	Homo sapiens	P63162	Peptide Array	15105431
Intra	CD2BP2	O95400	MAGED1	Homo sapiens	Q9Y5V3	NMR	16000308
Intra	CD2BP2	O95400	TXNL4A	Homo sapiens	P83876	Anti Tag CoIP	35271311
Intra	CD2BP2	O95400	TXNL4A	Homo sapiens	P83876	Anti Tag CoIP	28514442
Intra	CD2BP2	O95400	TXNL4A	Homo sapiens	P83876	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lobular Neoplasia	Lobular Carcinoma In Situ Lobular Carcinoma In Situ Of Breast Lobular Intraepithelial Neoplasia Non-Infiltrating Lobular Carcinoma Noninfiltrating Lobular Carcinoma Unspecified Site Noninfiltrating Lobular Carcinoma Of Breast Lobular Carcinoma In Situ Unspecified Site
Tolosa-Hunt Syndrome	Painful Ophthalmoplegia Tolosa Hunt Syndrome Nonspecific Inflammation Of The Cavernous Sinus Or Superior Orbital Fissure Ths Ophthalmoplegia, Painful

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS02225	CD2BP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD2BP2	VGNC	VGNC:27023
Canis familiaris	CD2BP2	VGNC	VGNC:38946
Rattus norvegicus	CD2BP2	RGD	RGD:1311741
Felis catus	CD2BP2	VGNC	VGNC:60606
Macaca mulatta	CD2BP2	VGNC	VGNC:97746
Mus musculus	CD2BP2	MGD	MGI:1917483
Others	CD2BP2	NCBI