C18orf25 - chromosome 18 open reading frame 25 Gene

Also Known as ARKL1; Ark2N; RNF111L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 147339

About C18orf25

This gene has 6 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 12.5), bone marrow (RPKM 9.9) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. [provided by Alliance of Genome Resources, Apr 2022]

C18orf25 Products (2)

mRNA Protein Name
NM_001008239.3 NP_001008240.1 uncharacterized protein C18orf25 isoform b
NM_145055.5 NP_659492.1 uncharacterized protein C18orf25 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
31341047 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of viral life cycle IDA
IDA: Inferred from direct assay
31341047 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in chromatin IDA
IDA: Inferred from direct assay
31341047 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C18orf25 Protein Structure

RNF111_N

RNF111_N: E3 ubiquitin-protein ligase Arkadia N-terminus (15 - 238)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

uncharacterized protein C18orf25

  • ARKadia-like 1

C18orf25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ARK2N Q96B23 SUMO1P1 Homo sapiens G2XKQ0
Validated Y2H
25416956
Intra
ARK2N Q96B23 SUMO1P1 Homo sapiens G2XKQ0
Y2H Prey Pooling
25416956
Intra
ARK2N Q96B23 SUMO1P1 Homo sapiens G2XKQ0
Y2H Array
25416956
Intra
ARK2N Q96B23 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
ARK2N Q96B23 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
ARK2N Q96B23 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
ARK2N Q96B23 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
ARK2N Q96B23 JAKMIP1 Homo sapiens Q96N16
Validated Y2H
32296183
Intra
ARK2N Q96B23 JAKMIP1 Homo sapiens Q96N16
Y2H Prey Pooling
32296183
Intra
ARK2N Q96B23 JAKMIP1 Homo sapiens Q96N16
Y2H Array
32296183
Intra
ARK2N Q96B23 MCRS1 Homo sapiens Q96EZ8
Y2H Array
32296183
Intra
ARK2N Q96B23 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
ARK2N Q96B23 MCRS1 Homo sapiens Q96EZ8
Y2H Prey Pooling
32296183
Intra
ARK2N Q96B23 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra
ARK2N Q96B23 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra
ARK2N Q96B23 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
ARK2N Q96B23 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
ARK2N Q96B23 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
ARK2N Q96B23 SUMO1 Homo sapiens P63165
Validated Y2H
25416956
Intra
ARK2N Q96B23 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
32296183
Intra
ARK2N Q96B23 SUMO1 Homo sapiens P63165
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 18q Deletion Syndrome

  • 18q- Syndrome

  • Monosomy 18q

  • Deletion Of Long Arm Of Chromosome 18

  • Chromosome 18q- Syndrome

  • Deletion 18q

  • 18q Deletion Syndrome

  • Distal 18q Deletion Syndrome

  • Chromosome 18 Long Arm Deletion Syndrome

  • Chromosome 18q Monosomy

  • Del Syndrome

  • Chromosome 18 Deletion Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01702 C18orf25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta C18orf25 VGNC VGNC:70416
Canis familiaris C18orf25 VGNC VGNC:52583
Mus musculus C18orf25 MGD MGI:2444951
Bos taurus C18orf25 VGNC VGNC:106663
Rattus norvegicus C18orf25 RGD RGD:1308601
Felis catus C18orf25 VGNC VGNC:60621
Others C18orf25 NCBI