CIAPIN1 - cytokine induced apoptosis inhibitor 1 Gene

Also Known as DRE2; CIAE2; PRO0915; Anamorsin

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57019

About CIAPIN1

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,428,187-57,447,385 (from NCBI)

This gene has 15 transcripts (splice variants) and 222 orthologues. Broad expression in testis (RPKM 38.4), placenta (RPKM 14.2) and 24 other tissues.

Summary

CIAPIN1 is a cytokine-induced inhibitor of Apoptosis with no relation to Apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]

CIAPIN1 Products (3)

mRNA Protein Name
NM_001308347.2 NP_001295276.1 anamorsin isoform 2
NM_001308358.2 NP_001295287.1 anamorsin isoform 3
NM_020313.4 NP_064709.2 anamorsin isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables 2 iron, 2 sulfur cluster binding IDA
IDA: Inferred from direct assay
27519415 GOA
enables iron ion binding EXP
EXP: Inferred from Experiment
21700214 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16957168 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
16957168 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIAPIN1 Protein Structure

CIAPIN1

CIAPIN1: Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis (222 - 303)

  • 0
  • 100
  • 200
  • 312 a.a.
Protein Preferred Names Protein Names

anamorsin

  • fe-S cluster assembly protein DRE2 homolog

CIAPIN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CIAPIN1 Q6FI81 NDOR1 Homo sapiens Q9UHB4
Y2H Array
32296183
Intra
CIAPIN1 Q6FI81 NDOR1 Homo sapiens Q9UHB4
Y2H Array
25416956
Intra
CIAPIN1 Q6FI81 NDOR1 Homo sapiens Q9UHB4
Y2H Prey Pooling
32296183
Intra
CIAPIN1 Q6FI81 NDOR1 Homo sapiens Q9UHB4
MAPPIT
32296183
Intra
CIAPIN1 Q6FI81 NDOR1 Homo sapiens Q9UHB4
Y2H Array
31515488
Intra
CIAPIN1 Q6FI81 NDOR1 Homo sapiens Q9UHB4
Validated Y2H
32296183
Intra
CIAPIN1 Q6FI81 NDOR1 Homo sapiens Q9UHB4
Anti Tag CoIP
33961781
Intra
CIAPIN1 Q6FI81 CACNB3 Homo sapiens P54284
Anti Tag CoIP
33961781
Intra
CIAPIN1 Q6FI81 BOLA2 Homo sapiens Q9H3K6
Anti Tag CoIP
27519415
Intra
CIAPIN1 Q6FI81 GLRX3 Homo sapiens O76003
MAPPIT
25416956
Intra
CIAPIN1 Q6FI81 GLRX3 Homo sapiens O76003
Y2H Array
32296183
Intra
CIAPIN1 Q6FI81 GLRX3 Homo sapiens O76003
Y2H
21516116
Intra
CIAPIN1 Q6FI81 GLRX3 Homo sapiens O76003
Y2H Array
29892012
Intra
CIAPIN1 Q6FI81 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
Intra
CIAPIN1 Q6FI81 GLRX3 Homo sapiens O76003
Anti Tag CoIP
25416956
Intra
CIAPIN1 Q6FI81 GLRX3 Homo sapiens O76003
Anti Tag CoIP
33961781
Intra
CIAPIN1 Q6FI81 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
Intra
CIAPIN1 Q6FI81 GLRX3 Homo sapiens O76003
Anti Tag CoIP
27519415
Intra
CIAPIN1 Q6FI81 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wolfram Syndrome 2

  • WFS2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02704 CIAPIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CIAPIN1 RGD RGD:1549737
Canis familiaris CIAPIN1 VGNC VGNC:39264
Felis catus CIAPIN1 VGNC VGNC:103729
Macaca mulatta CIAPIN1 VGNC VGNC:71117
Bos taurus CIAPIN1 VGNC VGNC:27357
Mus musculus CIAPIN1 MGD MGI:1922083
Others CIAPIN1 NCBI