BAG1 - BAG cochaperone 1 Gene

Also Known as HAP; BAG-1; RAP46

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 573

About BAG1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,252,471-33,264,708 (from NCBI)

This gene has 11 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in kidney (RPKM 19.7), colon (RPKM 18.5) and 25 other tissues.

Summary

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to Apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

BAG1 Products (4)

mRNA	Protein	Name
NM_001172415.2	NP_001165886.1	BAG family molecular chaperone regulator 1 isoform BAG-1S
NM_001349286.2	NP_001336215.1	BAG family molecular chaperone regulator 1 isoform BAG-1M
NM_001349299.2	NP_001336228.1	BAG family molecular chaperone regulator 1 isoform BAG1
NM_004323.6	NP_004314.6	BAG family molecular chaperone regulator 1 isoform BAG-1L

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables adenyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	24318877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9305631	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16207813	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in chaperone cofactor-dependent protein refolding	IDA IDA: Inferred from direct assay	12853476	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	9679980	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAG1 Protein Structure

ubiquitin

BAG

0
100
200
300
345 a.a.

Protein Preferred Names	Protein Names
BAG family molecular chaperone regulator 1	BCL2 associated athanogene 1

BAG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	BAG1	Q99933	HSPA8	Homo sapiens	Q96IS6	Validated Y2H	25416956
Intra	BAG1	Q99933	HSPA8	Homo sapiens	Q96IS6	Y2H Array	25416956
Intra	BAG1	Q99933	MLF2	Homo sapiens	Q15773	Anti Tag CoIP	25036637
Intra	BAG1	Q99933	MLF2	Homo sapiens	Q15773	Lumier	25036637
Intra	BAG1	Q99933	HSPA8	Homo sapiens	P11142	Validated Y2H	26871637
Intra	BAG1	Q99933	HSPA8	Homo sapiens	P11142	Y2H Prey Pooling	26871637
Intra	BAG1	Q99933	HSPA8	Homo sapiens	P11142	SPR	19800331
Intra	BAG1	Q99933	HSPA8	Homo sapiens	P11142	Y2H Array	26871637
Intra	BAG1	Q99933	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	25036637
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Lumier	25036637
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	33961781
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Y2H Array	25416956
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Y2H Array	32296183
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Y2H Prey Pooling	25416956
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Array	31515488
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Validated Y2H	26871637
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	26871637
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Array	26871637
Intra	BAG1	Q99933	q96be0_human	Homo sapiens	Q96BE0	Lumier	25036637
Intra	BAG1	Q99933	q53fc7_human	Homo sapiens	Q53FC7	Lumier	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

BAG1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81259	BAG1 Antibody (YA932)	WB	Human, Mouse, Rat
HY-P81259A	BAG1 Antibody (YA933)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P81259AA	BAG1 Antibody (YA933)(PBS only)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P84758	BAG1 Antibody (YA4455)	ICC/IF, FC, ELISA	Human
HY-P84758A	BAG1 Antibody (YA4455)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P85607	BAG1 Antibody (YA5299)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Coccidiosis	Intestinal Coccidiosis Enteric Coccidiosis
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-124611	JG-231		98.47%	Unkown
HY-124811	IRES-C11	Inhibitor	98.01%	Unkown
HY-RS01342	BAG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BAG1	VGNC	VGNC:84875
Felis catus	BAG1	VGNC	VGNC:69043
Bos taurus	BAG1	VGNC	VGNC:26405
Canis familiaris	BAG1	VGNC	VGNC:38363
Mus musculus	BAG1	MGD	MGI:108047
Rattus norvegicus	BAG1	RGD	RGD:1305203
Others	BAG1	NCBI