SFPQ - splicing factor proline and glutamine rich Gene

Also Known as PSF; POMP100; PPP1R140

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6421

About SFPQ

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,176,380-35,193,145 (from NCBI)

This gene has 11 transcripts (splice variants), 216 orthologues, 7 paralogues and is associated with 60 phenotypes. Ubiquitous expression in bone marrow (RPKM 84.2), skin (RPKM 34.9) and 25 other tissues.

Summary

Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within double-strand break repair via homologous recombination. Located in chromatin; nuclear matrix; and paraspeckles. [provided by Alliance of Genome Resources, Apr 2022]

SFPQ Products (1)

mRNA	Protein	Name
NM_005066.3	NP_005057.1	splicing factor, proline- and glutamine-rich

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	25765647	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16731528	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9848648	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	25765647	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	19874820	GOA
acts upstream of or within double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	20813759	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16731528	GOA
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15790595	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22783022	GOA
involved in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15790595	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25765647	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in chromatin	IDA IDA: Inferred from direct assay	16731528	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	19874820	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	19874820	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15790595	GOA
located in paraspeckles	IDA IDA: Inferred from direct assay	19874820	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFPQ Protein Structure

RRM_1

NOPS

0
200
400
600
707 a.a.

Protein Preferred Names	Protein Names
splicing factor, proline- and glutamine-rich	100 kDa DNA-pairing protein

SFPQ Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SFPQ	P23246	PTK6	Homo sapiens	Q13882	Pull Down	19439179
Intra	SFPQ	P23246	PTK6	Homo sapiens	Q13882	Anti Bait CoIP	19439179
Intra	SFPQ	P23246	PSPC1	Homo sapiens	Q8WXF1	Anti Tag CoIP	33961781
Intra	SFPQ	P23246	PSPC1	Homo sapiens	Q8WXF1	Confocal	16148043
Intra	SFPQ	P23246	SIN3A	Homo sapiens	Q96ST3	Pull Down	11259580
Intra	SFPQ	P23246	NONO	Homo sapiens	Q15233	PLA	25959826
Intra	SFPQ	P23246	PTBP1	Homo sapiens	P26599	CoIP	10653975
Intra	SFPQ	P23246	THRAP3	Homo sapiens	Q9Y2W1	Anti Tag CoIP	20932480
Intra	SFPQ	P23246	FMR1	Homo sapiens	Q06787	Y2H Pooling	21653829
Intra	SFPQ	P23246	SNRPA	Homo sapiens	P09012	Pull Down	9848648
Intra	SFPQ	P23246	SNRPA	Homo sapiens	P09012	Solution Sedimentation	9848648
Cross	SFPQ	P23246	EBNA-LP	Epstein-Barr virus	Q8AZK7	Anti Bait CoIP	18457437

Cross: Cross-species interaction Intra: Intraspecies interaction

SFPQ Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82195	SFPQ Antibody (YA1940)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P82195A	SFPQ Antibody (YA1940)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Renal Cell Carcinoma, Xp11-Associated	RCCX1 Mit Family Translocation Renal Cell Carcinoma Renal Cell Carcinoma, Papillary, 1 Carcinoma Associated With Mitf/Tfe Translocation Translocation Renal Cell Carcinoma Renal Cell Carcinoma Xp11-Associated Renal Cell Carcinoma Papillary 1 Carcinoma, Renal Cell, Xp11-Associated
Perivascular Epithelioid Cell Tumor	Pecoma Perivascular Epithelioid Cell Neoplasms Neoplasm With Perivascular Epithelioid Cell Differentiation
Dyslexia
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Alveolar Soft Part Sarcoma	ASPS Alveolar Soft-Part Sarcoma Sarcoma, Alveolar Soft Part Alveolar Soft Tissue Sarcoma Sarcoma Alveolar Soft Part Adult Alveolar Soft-Part Sarcoma Childhood Alveolar Soft-Part Sarcoma
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12770	SFPQ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22321	Sfpq Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28843	Sfpq Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SFPQ	VGNC	VGNC:103706
Felis catus	SFPQ	VGNC	VGNC:107619
Rattus norvegicus	SFPQ	RGD	RGD:727923
Bos taurus	SFPQ	VGNC	VGNC:34518
Mus musculus	SFPQ	MGD	MGI:1918764
Macaca mulatta	SFPQ	VGNC	VGNC:77184
Others	SFPQ	NCBI