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CDT1 - chromatin licensing and DNA replication factor 1 Gene

Also Known as DUP; RIS2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81620

About CDT1

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:88,803,789-88,809,258 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and is associated with 3 phenotypes. Biased expression in bone marrow (RPKM 13.5), placenta (RPKM 2.5) and 9 other tissues.

Summary

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

CDT1 Products (1)

mRNA	Protein	Name
NM_030928.4	NP_112190.2	DNA replication factor Cdt1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	11125146	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11125146	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in DNA replication checkpoint signaling	IDA IDA: Inferred from direct assay	14672932	GOA
involved in DNA replication preinitiation complex assembly	IDA IDA: Inferred from direct assay	11125146	GOA
involved in attachment of mitotic spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	22581055	GOA
involved in negative regulation of DNA-templated DNA replication	IDA IDA: Inferred from direct assay	19906994	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	19906994	GOA
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	26842564	GOA
involved in positive regulation of DNA-templated DNA replication	IDA IDA: Inferred from direct assay	11125146	GOA
involved in positive regulation of chromatin binding	IDA IDA: Inferred from direct assay	11125146	GOA
involved in regulation of DNA-templated DNA replication initiation	IDA IDA: Inferred from direct assay	11125146	GOA
involved in response to sorbitol	IDA IDA: Inferred from direct assay	21856198	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in kinetochore	IDA IDA: Inferred from direct assay	22581055	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11125146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDT1 Protein Structure

CDT1

0
100
200
300
400
500
546 a.a.

Protein Preferred Names	Protein Names
DNA replication factor Cdt1	Double parked, Drosophila, homolog of

CDT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CDT1	Q9H211	PCNA	Homo sapiens	P12004	Pull Down	16482215
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Peptide Array	15232106
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Pull Down	11125146
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	BFG-2H	27107012
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Pull Down	19906994
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	CoIP	11125146
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Pull Down	16482215
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	X-Ray Diffraction	19906994
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	SAXS	19906994
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Y2H	22581055
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	GMS	19906994
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Anti Tag CoIP	21543332
Intra	CDT1	Q9H211	GMNN	Homo sapiens	O75496	SPR	19906994
Intra	CDT1	Q9H211	CDC6	Homo sapiens	Q99741	Pull Down	14672932
Intra	CDT1	Q9H211	MCM6	Homo sapiens	Q14566	Anti Tag CoIP	26496610
Intra	CDT1	Q9H211	MCM6	Homo sapiens	Q14566	NMR	20202939
Intra	CDT1	Q9H211	NDC80	Homo sapiens	O14777	Pull Down	22581055
Intra	CDT1	Q9H211	NDC80	Homo sapiens	O14777	Anti Bait CoIP	22581055
Intra	CDT1	Q9H211	NDC80	Homo sapiens	O14777	Y2H	22581055

Cross: Cross-species interaction Intra: Intraspecies interaction

CDT1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80080	CDT1 Antibody (YA507)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Meier-Gorlin Syndrome 4	MGORS4 Meier-Gorlin Syndrome, Type 4
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Genitourinary Tract Anomalies
Microtia	Congenital Small Ears Hypoplasia Of Ear
Meier-Gorlin Syndrome 7	MGORS7 Meier-Gorlin Syndrome, Type 7
Meier-Gorlin Syndrome 5	MGORS5 Meier-Gorlin Syndrome, Type 5
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-128586	TAS4464		99.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-128586A	TAS4464 hydrochloride		98.91%	Unkown
HY-171180	AF615		99.55%	Unkown
HY-RS02427	CDT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20704	Cdt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27215	Cdt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDT1	VGNC	VGNC:27158
Canis familiaris	CDT1	VGNC	VGNC:39083
Macaca mulatta	CDT1	VGNC	VGNC:71092
Felis catus	CDT1	VGNC	VGNC:60721
Rattus norvegicus	CDT1	RGD	RGD:1309211
Mus musculus	CDT1	MGD	MGI:1914427
Others	CDT1	NCBI