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SRRM4 - serine/arginine repetitive matrix 4 Gene

Also Known as nSR100; KIAA1853; MU-MB-2.76

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84530

About SRRM4

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:118,981,541-119,163,051 (from NCBI)

This gene has 7 transcripts (splice variants) and 108 orthologues. Biased expression in brain (RPKM 5.9) and adrenal (RPKM 0.7).

Summary

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]

SRRM4 Products (1)

mRNA	Protein	Name
NM_194286.4	NP_919262.2	serine/arginine repetitive matrix protein 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	29961578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRRM4 Protein Structure

SRRM_C

0
100
200
300
400
500
611 a.a.

Protein Preferred Names	Protein Names
serine/arginine repetitive matrix protein 4	medulloblastoma antigen MU-MB-2.76

SRRM4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SRRM4	A7MD48	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	32296183
Intra	SRRM4	A7MD48	LUZP4	Homo sapiens	Q9P127	Validated Y2H	32296183
Intra	SRRM4	A7MD48	ZNF699	Homo sapiens	Q32M78	Y2H Array	32296183
Intra	SRRM4	A7MD48	ZNF699	Homo sapiens	Q32M78	Y2H Prey Pooling	32296183
Intra	SRRM4	A7MD48	ZNF699	Homo sapiens	Q32M78	Validated Y2H	32296183
Intra	SRRM4	A7MD48	AKAP17A	Homo sapiens	Q02040	Validated Y2H	32296183
Intra	SRRM4	A7MD48	AKAP17A	Homo sapiens	Q02040	Y2H Array	32296183
Intra	SRRM4	A7MD48	AKAP17A	Homo sapiens	Q02040	Y2H Prey Pooling	32296183
Intra	SRRM4	A7MD48	SNRNP70	Homo sapiens	P08621	Y2H Array	32296183
Intra	SRRM4	A7MD48	SNRNP70	Homo sapiens	P08621	Y2H Prey Pooling	32296183
Intra	SRRM4	A7MD48	SNRNP70	Homo sapiens	P08621	Validated Y2H	32296183
Intra	SRRM4	A7MD48	SRRM1	Homo sapiens	Q8IYB3	Validated Y2H	32296183
Intra	SRRM4	A7MD48	ZNF286A	Homo sapiens	Q9HBT8	Validated Y2H	32296183
Intra	SRRM4	A7MD48	SRSF11	Homo sapiens	Q05519-2	Validated Y2H	32296183
Intra	SRRM4	A7MD48	CLK1	Homo sapiens	P49759-3	Validated Y2H	32296183
Intra	SRRM4	A7MD48	ZRSR2P1	Homo sapiens	Q15695	Validated Y2H	32296183
Intra	SRRM4	A7MD48	RBM25	Homo sapiens	P49756	Validated Y2H	32296183
Intra	SRRM4	A7MD48	ZNF124	Homo sapiens	Q15973	Validated Y2H	32296183
Intra	SRRM4	A7MD48	CDC37	Homo sapiens	Q16543	Validated Y2H	32296183
Intra	SRRM4	A7MD48	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	SRRM4	A7MD48	LUC7L2	Homo sapiens	Q9Y383	Y2H Prey Pooling	32296183
Intra	SRRM4	A7MD48	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	32296183
Intra	SRRM4	A7MD48	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	32296183
Intra	SRRM4	A7MD48	RBM39	Homo sapiens	Q14498	Validated Y2H	32296183
Intra	SRRM4	A7MD48	RNPS1	Homo sapiens	Q15287	Validated Y2H	32296183
Intra	SRRM4	A7MD48	WDR5	Homo sapiens	P61964	Validated Y2H	32296183
Intra	SRRM4	A7MD48	U2AF1	Homo sapiens	Q01081	Validated Y2H	32296183
Intra	SRRM4	A7MD48	CLK4	Homo sapiens	Q9HAZ1	Validated Y2H	32296183
Intra	SRRM4	A7MD48	C16orf87	Homo sapiens	Q6PH81	Validated Y2H	32296183
Intra	SRRM4	A7MD48	ZRSR2	Homo sapiens	Q15696	Validated Y2H	32296183
Intra	SRRM4	A7MD48	RSRC1	Homo sapiens	Q96IZ7	Validated Y2H	32296183
Intra	SRRM4	A7MD48	MMTAG2	Homo sapiens	Q9BU76	Validated Y2H	32296183
Intra	SRRM4	A7MD48	SNIP1	Homo sapiens	Q8TAD8	Validated Y2H	32296183
Intra	SRRM4	A7MD48	SNIP1	Homo sapiens	Q8TAD8	Y2H Prey Pooling	32296183
Intra	SRRM4	A7MD48	SNIP1	Homo sapiens	Q8TAD8	Y2H Array	32296183
Intra	SRRM4	A7MD48	RBMX2	Homo sapiens	Q9Y388	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Dominant 27	DFNA27 Autosomal Dominant Nonsyndromic Deafness 27 Autosomal Dominant Deafness 27 Deafness, Autosomal Dominant, 27
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13788	SRRM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SRRM4	MGD	MGI:1916205
Canis familiaris	SRRM4	VGNC	VGNC:46814
Bos taurus	SRRM4	VGNC	VGNC:35295
Macaca mulatta	SRRM4	VGNC	VGNC:78011
Rattus norvegicus	SRRM4	RGD	RGD:1560213
Felis catus	SRRM4	VGNC	VGNC:65692
Others	SRRM4	NCBI