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RNF14 - ring finger protein 14 Gene

Also Known as ARA54; HFB30; TRIAD2; HRIHFB2038

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9604

About RNF14

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,949,337-141,990,292 (from NCBI)

This gene has 16 transcripts (splice variants), 285 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 10.0), thyroid (RPKM 8.1) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with Androgen Receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate Cancer. This protein also interacts with class III ubiquitin-conjugating Enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

RNF14 Products (6)

mRNA	Protein	Name
NM_001201365.2	NP_001188294.1	E3 ubiquitin-protein ligase RNF14 isoform 1
NM_004290.5	NP_004281.1	E3 ubiquitin-protein ligase RNF14 isoform 1
NM_183398.3	NP_899645.1	E3 ubiquitin-protein ligase RNF14 isoform 2
NM_183399.3	NP_899646.1	E3 ubiquitin-protein ligase RNF14 isoform 1
NM_183400.3	NP_899647.1	E3 ubiquitin-protein ligase RNF14 isoform 1
NM_183401.3	NP_899648.1	E3 ubiquitin-protein ligase RNF14 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	19345326	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10085091	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	27863242	GOA
enables ubiquitin-like protein transferase activity	IDA IDA: Inferred from direct assay	11322894	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19345326	GOA
involved in protein K6-linked ubiquitination	IDA IDA: Inferred from direct assay	27863242	GOA
involved in protein ubiquitination	IEP IEP: Inferred from expression pattern	11322894	GOA
involved in protein-RNA covalent cross-linking repair	IDA IDA: Inferred from direct assay	37951215	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19345326	GOA
involved in regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	19345326	GOA
involved in regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	23449499	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	27863242	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	27863242	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11322894	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	27863242	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11322894	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF14 Protein Structure

RWD

IBR

0
100
200
300
400
474 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF14	androgen receptor associated protein 54

RNF14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RNF14	Q9UBS8	DACH1	Homo sapiens	Q9UI36-2	Validated Y2H	32296183
Intra	RNF14	Q9UBS8	AR	Homo sapiens	P10275	Anti Bait CoIP	19345326
Intra	RNF14	Q9UBS8	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	RNF14	Q9UBS8	UBE2D1	Homo sapiens	P51668	Validated Y2H	25416956
Intra	RNF14	Q9UBS8	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	25416956
Intra	RNF14	Q9UBS8	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Prey Pooling	25416956
Intra	RNF14	Q9UBS8	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Microcephaly With Spastic Quadriplegia	Recessive Microcephaly With Spastic Quadriplegia
Diencephalic-Mesencephalic Junction Dysplasia Syndrome 1	DMJDS1 Microcephaly, Seizures, Spasticity, And Brain Calcifications Missbc Microcephaly With Spastic Quadriplegia Dysplasia, Diencephalic-Mesencephalic Junction, Syndrome 1
Diencephalic-Mesencephalic Junction Dysplasia	Diencephalic-Mesencephalic Junction Dysplasia Syndrome
Coats Disease	Exudative Retinopathy Retinal Telangiectasis Coats' Disease Leber Miliary Aneurysm Coats' Syndrome Congenital Retinal Telangiectasia
Aceruloplasminemia	Cerebellar Ataxia Hypoceruloplasminemia Hemosiderosis, Systemic, Due To Aceruloplasminemia Familial Apoceruloplasmin Deficiency Hereditary Ceruloplasmin Deficiency Deficiency Of Ferroxidase Hypoceruloplasminemia, Hereditary Ceruloplasmin Deficiency Systemic Hemosiderosis Due To Aceruloplasminemia ACERULOP
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-W854844A	(E)-JP-2-196 TFA	Ligand	97.89%	Unkown
HY-177569	NVS1.1	Degrader	/	Unkown
HY-177757	NVS2.1	Degrader	99.9%	Unkown
HY-RS12052	RNF14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21735	Rnf14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28252	Rnf14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF14	MGD	MGI:1929668
Felis catus	RNF14	VGNC	VGNC:64671
Rattus norvegicus	RNF14	RGD	RGD:1589576
Canis familiaris	RNF14	VGNC	VGNC:45633
Bos taurus	RNF14	VGNC	VGNC:34024
Macaca mulatta	RNF14	VGNC	VGNC:84488
Others	RNF14	NCBI