RNF14 - ring finger protein 14 Gene

Also Known as ARA54; HFB30; TRIAD2; HRIHFB2038

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9604

About RNF14

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,949,337-141,990,292 (from NCBI)

This gene has 16 transcripts (splice variants), 285 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 10.0), thyroid (RPKM 8.1) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with Androgen Receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate Cancer. This protein also interacts with class III ubiquitin-conjugating Enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

RNF14 Products (6)

mRNA Protein Name
NM_001201365.2 NP_001188294.1 E3 ubiquitin-protein ligase RNF14 isoform 1
NM_004290.5 NP_004281.1 E3 ubiquitin-protein ligase RNF14 isoform 1
NM_183398.3 NP_899645.1 E3 ubiquitin-protein ligase RNF14 isoform 2
NM_183399.3 NP_899646.1 E3 ubiquitin-protein ligase RNF14 isoform 1
NM_183400.3 NP_899647.1 E3 ubiquitin-protein ligase RNF14 isoform 1
NM_183401.3 NP_899648.1 E3 ubiquitin-protein ligase RNF14 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear androgen receptor binding IPI
IPI: Inferred from physical interaction
19345326 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10085091 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
27863242 GOA
enables ubiquitin-like protein transferase activity IDA
IDA: Inferred from direct assay
11322894 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19345326 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
27863242 GOA
involved in protein ubiquitination IEP
IEP: Inferred from expression pattern
11322894 GOA
involved in protein-RNA covalent cross-linking repair IDA
IDA: Inferred from direct assay
37951215 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19345326 GOA
involved in regulation of androgen receptor signaling pathway IDA
IDA: Inferred from direct assay
19345326 GOA
involved in regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
23449499 GOA
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
27863242 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
27863242 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11322894 GOA
is active in cytosolic ribosome IDA
IDA: Inferred from direct assay
27863242 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11322894 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF14 Protein Structure

RWD

RWD: RWD domain (4 - 133)

IBR

IBR: IBR domain, a half RING-finger domain (290 - 350)

IBR

IBR: IBR domain, a half RING-finger domain (381 - 436)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF14

  • androgen receptor associated protein 54

RNF14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF14 Q9UBS8 DACH1 Homo sapiens Q9UI36-2
Validated Y2H
32296183
Intra
RNF14 Q9UBS8 AR Homo sapiens P10275
Anti Bait CoIP
19345326
Intra
RNF14 Q9UBS8 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
Intra
RNF14 Q9UBS8 UBE2D1 Homo sapiens P51668
Validated Y2H
25416956
Intra
RNF14 Q9UBS8 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
25416956
Intra
RNF14 Q9UBS8 UBE2D4 Homo sapiens Q9Y2X8
Y2H Prey Pooling
25416956
Intra
RNF14 Q9UBS8 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microcephaly With Spastic Quadriplegia

  • Recessive Microcephaly With Spastic Quadriplegia
Diencephalic-Mesencephalic Junction Dysplasia Syndrome 1

  • DMJDS1

  • Microcephaly, Seizures, Spasticity, And Brain Calcifications

  • Missbc

  • Microcephaly With Spastic Quadriplegia

  • Dysplasia, Diencephalic-Mesencephalic Junction, Syndrome 1
Diencephalic-Mesencephalic Junction Dysplasia

  • Diencephalic-Mesencephalic Junction Dysplasia Syndrome
Coats Disease

  • Exudative Retinopathy

  • Retinal Telangiectasis

  • Coats' Disease

  • Leber Miliary Aneurysm

  • Coats' Syndrome

  • Congenital Retinal Telangiectasia
Aceruloplasminemia

  • Cerebellar Ataxia

  • Hypoceruloplasminemia

  • Hemosiderosis, Systemic, Due To Aceruloplasminemia

  • Familial Apoceruloplasmin Deficiency

  • Hereditary Ceruloplasmin Deficiency

  • Deficiency Of Ferroxidase

  • Hypoceruloplasminemia, Hereditary

  • Ceruloplasmin Deficiency

  • Systemic Hemosiderosis Due To Aceruloplasminemia

  • ACERULOP
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W854844A (E)-JP-2-196 TFA Ligand 97.89% Unkown
HY-177569 NVS1.1 Degrader / Unkown
HY-177757 NVS2.1 Degrader 99.9% Unkown
HY-RS12052 RNF14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21735 Rnf14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28252 Rnf14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RNF14 MGD MGI:1929668
Felis catus RNF14 VGNC VGNC:64671
Rattus norvegicus RNF14 RGD RGD:1589576
Canis familiaris RNF14 VGNC VGNC:45633
Bos taurus RNF14 VGNC VGNC:34024
Macaca mulatta RNF14 VGNC VGNC:84488
Others RNF14 NCBI