Glutaminase
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Glutaminase (GLS) is a metabolic enzyme. Glutaminase catalyzes the conversion of glutamine to glutamate, which is a key step in glutaminolysis. The glutaminase isoenzymes GLS and GLS2 differ in their expression patterns and functional roles: GLS exhibits oncogenic properties, whereas GLS2 is regarded as a tumor suppressor. Glutaminase expression levels correlate with the degree of tumor malignancy.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 9001-47-2
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Glutaminase regulates glutamine metabolism, and its expression level correlates with the malignancy of tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
EC Number
3.5.1.2
Specific Activity
50 - 200 U/mg protein
Unit Definition
One unit is defined as the amount of enzyme that will deaminate 1.0 μmole of L-glutamine per min at pH 4.9 at 37°C
Chemical Information
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CAS. Nr. 9001-47-2
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Appearance Solid
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Color Off-white to light yellow
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SMILES
[Glutaminase]
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Synonyms
GLS
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 1 mg/mL (Need ultrasonic and warming)
Protokoll
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Matés JM, et al. Glutaminase isoenzymes in the metabolic therapy of cancer. Biochimica et biophysica acta. Reviews on cancer. 2018 Dec;1870(2):158-164. [Content Brief]
[2]. Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer cell. 2010 Sep 14;18(3):207-19. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Glutaminase Related Classifications
HY-P2760 Related Classifications
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