GPLGIAGQC
GPLGIAGQC is an MMP2-cleavable peptide. In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by MMP2 between the glycine and isoleucine residues. After MMP2-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles.
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- CAS. Nr.: 1423719-70-3
- Formel: C34H58N10O11S
- Molecular Weight:814.95
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
The GPLGIAGQC peptide (10-40 nM MMP2; 24 h) acts as an MMP2-cleavable linker in AP-PP-DOX nanoparticles, enabling sustained, MMP2-dependent release of DOX with minimal leakage in MMP2-deficient conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1423719-70-3
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Molecular Weight 814.95
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Formel C34H58N10O11S
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Sequence
Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln-Cys
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Sequence Shortening
GPLGIAGQC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Wang MZ, et al. A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy. Molecules. 2020 Jul 7;25(13):3096. [Content Brief]
[2]. Liu XY, et al. A nano-innate immune system activator for cancer therapy in a 4T1 tumor-bearing mouse model. J Nanobiotechnology. 2022 Jan 29;20(1):54. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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