Art. -Nr.: HY-125402

GSK-843

(Synonyms: GSK'843)

8 Cited Publications

Kundenbewertung

Based on 8 publication(s) in Google Scholar

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 8.6 nM, and inhibits kinase activity with an IC₅₀ of 6.5 nM. GSK-843 can be used for the research of inflammation.

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Reinheit: 99.53%
CAS. Nr.: 1601496-05-2
Formel: C₁₉H₁₅N₅S₂
Molecular Weight:377.49

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 1 year , -20°C, 6 months

GSK-843 Chemical Structure

CAS. Nr.: 1601496-05-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (8)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

RIPK3

Alle RIP kinase Isoform-spezifische Produkte anzeigen :

In Vitro

GSK-843 (3-10 μM; 18 h) induces apoptosis^[1].
GSK-843 (0.3-3 μM; 18 h) suppresses TNF-induced death and virus-induced cell necrosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SVEC, L929, 3T3SA and mouse embryo fibroblast (MEF)
Concentration:

3 and 10 μM
Incubation Time:

18 hours
Result:

Decreased the cell viability of SVEC, L929, 3T3SA and MEF cells, and induced caspase activation followed by apoptotic cell death.

Cell Viability Assay^[2]

Cell Line:

3T3-SA and SVEC4-10 cells
Concentration:

0.3, 1 and 3 μM
Incubation Time:

18 hours
Result:

Dose-dependently suppressed TNF-induced death and virus-induced necrosis to improved cell viability.

Chemical Information

CAS. Nr. 1601496-05-2
Appearance Solid
Molecular Weight 377.49
Formel C₁₉H₁₅N₅S₂
Color Light yellow to yellow
SMILES

NC1=NC=C(C2=CC(C)=NN2C)C3=C1C(C4=CC=C(SC=N5)C5=C4)=CS3
Synonyms

GSK'843
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (8)

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Journal Impact Factor

Nat Commun

Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro. [Abstract]

2025 May 8;16(1):4288. PMID: 40341069
Sci Adv

Reprogramming RIPK3-induced cell death in malignant B cells promotes immune-mediated tumor control. [Abstract]

2025 Aug 15;11(33):eadv0871. PMID: 40815638
Cell Death Differ

cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A. [Abstract]

2025 Dec 12. PMID: 41381861
Cancer Lett

Myeloid-derived suppressor cells deficient in cholesterol biosynthesis promote tumor immune evasion. [Abstract]

2023 Jun 28:564:216208. PMID: 37150500
Cell Death Discov

Loss of Ripk3 attenuated neutrophil accumulation in a lipopolysaccharide-induced zebrafish inflammatory model. [Abstract]

2022 Feb 26;8(1):88. PMID: 35220408
Cell Rep

Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis. [Abstract]

2026 Mar 20;45(4):117130. PMID: 41863805
Mol Immunol

Enhanced RIPK3 kinase activity-dependent lytic cell death in M1 but not M2 macrophages. [Abstract]

2021 Jan:129:86-93. PMID: 33221042
University of Cologne

2024.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (132.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6491 mL

13.2454 mL

26.4908 mL

5 mM

0.5298 mL

2.6491 mL

5.2982 mL

10 mM

0.2649 mL

1.3245 mL

2.6491 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 4.8 mg/mL (12.72 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 4.8 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (48.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (5.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95. [Content Brief]

[2]. Kaiser WJ, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013 Oct 25;288(43):31268-79. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6491 mL	13.2454 mL	26.4908 mL	66.2269 mL
	5 mM	0.5298 mL	2.6491 mL	5.2982 mL	13.2454 mL
	10 mM	0.2649 mL	1.3245 mL	2.6491 mL	6.6227 mL
	15 mM	0.1766 mL	0.8830 mL	1.7661 mL	4.4151 mL
	20 mM	0.1325 mL	0.6623 mL	1.3245 mL	3.3113 mL
	25 mM	0.1060 mL	0.5298 mL	1.0596 mL	2.6491 mL
	30 mM	0.0883 mL	0.4415 mL	0.8830 mL	2.2076 mL
	40 mM	0.0662 mL	0.3311 mL	0.6623 mL	1.6557 mL
	50 mM	0.0530 mL	0.2649 mL	0.5298 mL	1.3245 mL
	60 mM	0.0442 mL	0.2208 mL	0.4415 mL	1.1038 mL
	80 mM	0.0331 mL	0.1656 mL	0.3311 mL	0.8278 mL
	100 mM	0.0265 mL	0.1325 mL	0.2649 mL	0.6623 mL

Keywords

GSK-843

8 Cited Publications

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GSK-843

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) GSK-843

Alle RIP kinase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (8)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

GSK-843

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) GSK-843

Alle RIP kinase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (8)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

GSK-843 Related Classifications

HY-125402 Related Classifications