Heliquinomycin
Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth.
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- CAS. Nr.: 178182-49-5
- Formel: C33H30O17
- Molecular Weight:698.58
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Speicherung:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biologische Aktivität
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Chemical Information
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Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen
MoreAlle Topoisomerase Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Beschreibung
IC50 & Target
[2]|
Helicase |
Topoisomerase I |
Topoisomerase II |
In Vitro
Heliquinomycin (18 h) shows strong inhibitory activity against Gram-positive bacteria strains with MIC values of 0.1-0.39 μM[1].
Heliquinomycin inhibits the growth of HeLa S3, LI210 leukemia, IMC,carcinoma, B16 meranoma cells, with IC50s of 0-1.6 μg/mL[1].
Heliquinomycin (30 and 100 μg/mL) inhibits topoisomerase II and I enzymes activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 178182-49-5
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Appearance Solid
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Molecular Weight 698.58
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Formel C33H30O17
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Color Brown to red
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SMILES
OC1=C([C@H]([C@]2(OC3=C(O)C(C(OC(C(OC)=O)=C4)=O)=C4C=C3C[C@H]2O)O5)O[C@H]6C[C@H]([C@H]([C@@H](O6)C)O)OC)C5=C(O)C(C(C(OC)=C7)=O)=C1C7=O
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Initial Source
Streptomyces sp. MJ929-SF2.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Aug;49(8):752-7. [Content Brief]
[2]. Chino M,et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo). 1998 May;51(5):480-6. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Heliquinomycin Related Classifications
HY-105387 Related Classifications
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