Hericenone C
Based on 1 Customer Validation
Hericenone C is a metabolite derived from Hericium erinaceus. Hericenone C inhibits LPS (HY-D1056)-induced NRE::Luc luciferase activity, reduces phosphorylation of p65 and inhibits NF-κB signaling. Hericenone C exhibits neuroprotective effect.
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- Reinheit : 98.07%
- CAS. Nr.: 137592-03-1
- Formel: C35H54O6
- Molecular Weight:570.80
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Hericenone C (2.5-20 μM, 1 h) inhibits luciferase activity and reduces p-P65 levels in LPS (HY-D1056)-induced NIH3T3 cells expressing NRE::Luc[1].
Hericenone C (40 μM, 1 h) inhibits the Formalin-induced increase in IL-6 mRNA expression and reduces the percentage of CD11c-positive cells in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Formalin-induced nociceptive model of male ICR mice[1]
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Dosage:2.5, 5 and 10 mg/kg
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Administration:Intraperitoneally injection, 45 mins before formalin
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Result:Reduced licking/biting timeof the second phase (10-45 min).
Showed no significant effect on the first phase (0-10 min).
Reduced the accumulation of CD11c-positive cells in the paw epidermis and inhibited the activation of p-P65 in CD11c-positive cells.
Chemical Information
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CAS. Nr. 137592-03-1
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Appearance Solid
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Molecular Weight 570.80
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Formel C35H54O6
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Color White to off-white
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SMILES
C/C(C)=C\C(C/C(C)=C/CC1=C(C=C(C(C=O)=C1O)COC(CCCCCCCCCCCCCCC)=O)OC)=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
In Vitro:
Ethanol : 50 mg/mL (87.60 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.7519 mL | 8.7596 mL | 17.5193 mL | 43.7982 mL |
| 5 mM | 0.3504 mL | 1.7519 mL | 3.5039 mL | 8.7596 mL | |
| 10 mM | 0.1752 mL | 0.8760 mL | 1.7519 mL | 4.3798 mL | |
| 15 mM | 0.1168 mL | 0.5840 mL | 1.1680 mL | 2.9199 mL | |
| 20 mM | 0.0876 mL | 0.4380 mL | 0.8760 mL | 2.1899 mL | |
| 25 mM | 0.0701 mL | 0.3504 mL | 0.7008 mL | 1.7519 mL | |
| 30 mM | 0.0584 mL | 0.2920 mL | 0.5840 mL | 1.4599 mL | |
| 40 mM | 0.0438 mL | 0.2190 mL | 0.4380 mL | 1.0950 mL | |
| 50 mM | 0.0350 mL | 0.1752 mL | 0.3504 mL | 0.8760 mL | |
| 60 mM | 0.0292 mL | 0.1460 mL | 0.2920 mL | 0.7300 mL | |
| 80 mM | 0.0219 mL | 0.1095 mL | 0.2190 mL | 0.5475 mL |
Hericenone C Related Classifications
HY-N16500 Related Classifications
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