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iCRT 14

20 Cited Publications
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Based on 20 publication(s) in Google Scholar

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase.

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  • Reinheit: 99.72%
  • CAS. Nr.: 677331-12-3
  • Formel: C21H17N3O2S
  • Molecular Weight:375.44
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • iCRT 14 Chemical Structure
    iCRT 14 Chemical Structure
  • Experimental Validation Results for iCRT 14
  • Experimental Validation Results for iCRT 14
  • Experimental Validation Results for iCRT 14
  • Experimental Validation Results for iCRT 14
  • Experimental Validation Results for iCRT 14
  • Experimental Validation Results for iCRT 14
  • Experimental Validation Results for iCRT 14
CAS. Nr.: 677331-12-3
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  • iCRT 14 Chemical Structure
    iCRT 14 Chemical Structure
    1/16
  • 1/16

    iCRT 14 purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2024 Jun 1:26:101111. [Abstract]

    Customer Validation
     The COOME was treated with or without Wnt inhibitor ICRT 14 (1, 3 or 5 μM) for 24 h. Then the treated COOME was co-culture with iMSCs for 3 days. Osteogenic differentiation was evaluated using AP staining.

  • 1/16

    iCRT 14 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Dec 22;25(1):217. [Abstract]

    Customer Validation
     H1650 were pre-treated for 1 h with either 100 nM iCRT14 or 1 nM LGK-974 and were infected with Vpp overnight in the presence of the inhibitors.

  • 1/16

    iCRT 14 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Dec 22;25(1):217. [Abstract]

    Customer Validation
     HEK293T cells were pre-treated for 1 h with either 10 nM iCRT14 or 0.01 nM LGK-974 and were infected with Vpp overnight in the presence of the inhibitors.

  • 1/16

    iCRT 14 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Dec 22;25(1):217. [Abstract]

    Customer Validation
     Effect of disruption of β-catenin pathway on ACE2 RNA levels. H1650 cells were treated with the indicated concentrations of iCRT14 for 24 h and were subsequently harvested for qRT-PCR. The levels of ACE2 RNA were normalized by GAPDH RNA.

  • 1/16

    iCRT 14 purchased from MedChemExpress. Usage Cited in: Neurotherapeutics. 2021 Jan;18(1):601-614. [Abstract]

    Customer Validation
     On day 16, 18 rats were divided into three groups that received an injection of vehicle, 10 or 30 mg/kg of iCRT14 (ip, single dose). The 30 mg/kg of iCRT14 significantly increased the mechanical threshold for 3 h compared with that in the vehicle group (n = 6, p < 0.05).

  • 1/16

    iCRT 14 purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2020 Sep;248:108804. [Abstract]

    Customer Validation
     MDBK cells in 60 mm dishes are pretreated with iCRT14 (10 μM) for 2 hours, after which they are mock infected or infected with BoHV-1 at an MOI of 0.1 in the presence of iCRT14 (10 μM) or DMSO control. After infection for 24 h, the cell lysates are prepared for Western blotting to detect the expression of JNK.

  • 1/16

    iCRT 14 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Apr 1;9(4):433. [Abstract]

    Customer Validation
     rECA109 and rKyse150 cells show preferential activation of DNA damage checkpoint responses upon exposure to ionizing radiation (IR) relative to parental cells. And WNT1 promoted preferential activation of DNA damage response while iCRT14 hinders it.

  • iCRT 14