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Art. -Nr.: HY-112255

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J9

J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC₅₀ of 28 μM in combination with Dexamethasone.

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CAS. Nr.: 947018-15-7
Formel: C₁₂H₁₂N₄
Molecular Weight:212.25

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

J9 Chemical Structure

CAS. Nr.: 947018-15-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
CUTLL1	EC₅₀	28 μM Compound: 1, J9	Growth inhibition of human CUTLL1 cells in presence of 1 uM dexamethasone after 48 hrs by alamar blue assay Growth inhibition of human CUTLL1 cells in presence of 1 uM dexamethasone after 48 hrs by alamar blue assay	[PMID: 25050160]
CUTLL1	EC₅₀	≥100 μM Compound: 1, J9	Growth inhibition of human CUTLL1 cells in absence of 1 uM dexamethasone after 48 hrs by alamar blue assay Growth inhibition of human CUTLL1 cells in absence of 1 uM dexamethasone after 48 hrs by alamar blue assay	[PMID: 25050160]

Chemical Information

CAS. Nr. 947018-15-7
Molecular Weight 212.25
Formel C₁₂H₁₂N₄
SMILES

NC1=NC=C(C2=CC=NC=C2)C(C3CC3)=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cantley AM, et al. Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL). ACS Med Chem Lett. 2014 Apr 25;5(7):754-9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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