country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-186286

Copy Link Print Information

KRAS-IN-63

KRAS-IN-63 is a KRAS^G12 inhibitor with a pIC₅₀ of 8.11. KRAS-IN-63 can be used in lung cancer-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₁H₃₁ClN₆O₂
Molecular Weight:555.07

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS-IN-63 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

KRAS-IN-63 is a KRAS^G12 inhibitor with a pIC₅₀ of 8.11. KRAS-IN-63 can be used in lung cancer-related research^[1].

IC₅₀ & Target^[1]

KRASG12

8.11 (pIC₅₀)

Alle Ras Isoform-spezifische Produkte anzeigen :

In Vitro

KRAS-IN-63 (C9) tightly docks into the Switch-II pocket of KRAS^G12C, and forms a network of hydrogen bonds, electrostatic interactions and hydrophobic interactions with key pocket residues (SER17, THR35, ASP33)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 555.07
Formel C₃₁H₃₁ClN₆O₂
SMILES

O=C1N(C2=C[C@]([C@]3=C4C(NN=C4)=CC=C3C)=C(C=C2C(N5CCN(CC5)C(C)=O)=N1)Cl)C6=C(C=CC=C6)C(C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Stephen Adebayo O, et al. QSAR-guided discovery of novel KRAS inhibitors for lung cancer therapy. Frontiers in bioinformatics. 2025;5:1663846. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

KRAS-IN-63

Alle Ras Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

KRAS-IN-63 Related Classifications

HY-186286 Related Classifications