Art. -Nr.: HY-116038

Kulinone

Name: Kulinone
Brand: MedChemExpress
SKU: HY-116038
Price: 338.00 USD
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Kulinone is a triterpenoid anticancer agent. Kulinone induces cytotoxic effects in lung cancer and gastric cancer cells. Kulinone is isolated from the bark of Melia azedarach. Kulinone is applicable to research related to lung cancer and gastric cancer.

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Reinheit: 99.75%
CAS. Nr.: 21688-61-9
Formel: C₃₀H₄₈O₂
Molecular Weight:440.70

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Kulinone Chemical Structure

CAS. Nr.: 21688-61-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	3.61 μg/mL Compound: 9	Growth inhibition of human BxPC3 cells Growth inhibition of human BxPC3 cells	[PMID: 12502333]
DU-145	GI₅₀	3.6 μg/mL Compound: 9	Growth inhibition of human DU145 cells Growth inhibition of human DU145 cells	[PMID: 12502333]
KM-20L2	GI₅₀	3.6 μg/mL Compound: 9	Growth inhibition of human KM20L2 cells Growth inhibition of human KM20L2 cells	[PMID: 12502333]
MCF7	GI₅₀	3.6 μg/mL Compound: 9	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 12502333]
MCF7	IC₅₀	42.5 μg/mL Compound: 13	Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay	[PMID: 20961091]
NCI-H460	GI₅₀	3.6 μg/mL Compound: 9	Growth inhibition of human NCI-H460 cells Growth inhibition of human NCI-H460 cells	[PMID: 12502333]
P388	ED₅₀	1.7 μg/mL Compound: 13	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 20961091]
P388	ED₅₀	4.6 μg/mL Compound: 9	Growth inhibition of mouse P388 cells Growth inhibition of mouse P388 cells	[PMID: 12502333]
SF-268	GI₅₀	3.6 μg/mL Compound: 9	Growth inhibition of human SF268 cells Growth inhibition of human SF268 cells	[PMID: 12502333]
U2OS	IC₅₀	6.9 μg/mL Compound: 13	Cytotoxicity against human U2OS cells after 36 hrs by MTT assay Cytotoxicity against human U2OS cells after 36 hrs by MTT assay	[PMID: 20961091]

In Vitro

Kulinone (Compound 7) exhibits cytotoxic activity against A549, H460, and HGC27 human cancer cell lines at 72 h, with IC₅₀ values of 6.2, 7.8, and 5.6 µg/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 21688-61-9
Appearance Solid
Molecular Weight 440.70
Formel C₃₀H₄₈O₂
Color White to off-white
SMILES

C[C@@]12C3=CC[C@](C(C)(C(CC4)=O)C)([H])[C@@]4(C)[C@@]3([H])CC[C@]1([C@]([C@H](C2)O)([H])[C@H](C)CC/C=C(C)\C)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (113.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2691 mL

11.3456 mL

22.6912 mL

5 mM

0.4538 mL

2.2691 mL

4.5382 mL

10 mM

0.2269 mL

1.1346 mL

2.2691 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.25 mg/mL (2.84 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (2.84 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wu SB, et al. Cytotoxic triterpenoids and steroids from the bark of Melia azedarach. Planta medica. 2011 Jun;77(9):922-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2691 mL	11.3456 mL	22.6912 mL	56.7279 mL
	5 mM	0.4538 mL	2.2691 mL	4.5382 mL	11.3456 mL
	10 mM	0.2269 mL	1.1346 mL	2.2691 mL	5.6728 mL
	15 mM	0.1513 mL	0.7564 mL	1.5127 mL	3.7819 mL
	20 mM	0.1135 mL	0.5673 mL	1.1346 mL	2.8364 mL
	25 mM	0.0908 mL	0.4538 mL	0.9076 mL	2.2691 mL
	30 mM	0.0756 mL	0.3782 mL	0.7564 mL	1.8909 mL
	40 mM	0.0567 mL	0.2836 mL	0.5673 mL	1.4182 mL
	50 mM	0.0454 mL	0.2269 mL	0.4538 mL	1.1346 mL
	60 mM	0.0378 mL	0.1891 mL	0.3782 mL	0.9455 mL
	80 mM	0.0284 mL	0.1418 mL	0.2836 mL	0.7091 mL
	100 mM	0.0227 mL	0.1135 mL	0.2269 mL	0.5673 mL

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Kulinone

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Kulinone Related Classifications

HY-116038 Related Classifications

Bioz