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Art. -Nr.: HY-149102

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LE 28

Name: LE 28
Brand: MedChemExpress
SKU: HY-149102
Availability: PreOrder

1 Cited Publications

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LE 28 is a selective and activity-dependent legumain probe. LE 28 becomes fluorescent only upon binding active legumain. LE 28 can be used for research of cancers and inflammatory diseases.

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CAS. Nr.: 1416080-97-1
Formel: C₁₀₂H₁₁₁N₁₀O₂₁S₃⁺
Molecular Weight:1909.22

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

LE 28 Chemical Structure

CAS. Nr.: 1416080-97-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

LE 28 is a selective and activity-dependent legumain probe. LE 28 becomes fluorescent only upon binding active legumain. LE 28 can be used for research of cancers and inflammatory diseases^[1].

In Vitro

LE 28 (0-5 μM, 1 h) can label legumain in RAW cell lysates by lysis and fluorescent SDS-PAGE method^[1].
LE 28 (1 μM 5 h) colocalizes well with Lysotracker in in RAW cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LE 28 (2 mg/kg, i.v.) produces specific signal in the kidney of mice^[1].
LE 28 (2 mg/kg, i.v.) signal is detected around the periphery of the tumors at 30 min, with maximal contrast between tumor and normal tissue achieved after 7 hours in HCT-116 xenograft tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HCT-116 xenograft tumor model^[1]
Dosage:

2 mg/kg
Administration:

i.v.
Result:

Detected the signal around the periphery of the tumors in as early as 30 min, with maximal contrast between tumor and normal tissue achieved after seven hours, and the signal remained constant up to 28 h.

Chemical Information

CAS. Nr. 1416080-97-1
Molecular Weight 1909.22
Formel C₁₀₂H₁₁₁N₁₀O₂₁S₃⁺
SMILES

O=S(C1=C(C=CC=C1)C2=C(C=CC(N3C4=CC=CC=C4CC3)=C5)C5=[O+]C6=C2C=CC(N7C8=CC=CC=C8CC7)=C6)(N9CCC(CC9)C(NCCCNC(C%10=CC(C)=C(C(C)=C%10)C(OCC([C@H](CC(O)=O)NC([C@H]%11N(CCC%11)C([C@H](CCC(O)=O)NC(CCCCC[N+]%12=C(/C=C/C=C/C=C%13N(C%14=CC=C(S(=O)(O)=O)C=C%14C\%13(C)C)CC)C(C)(C)C%15=CC(S(=O)([O-])=O)=CC=C%12%15)=O)=O)=O)=O)=O)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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2026 Apr 30.

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Edgington LE, et al. Functional imaging of legumain in cancer using a new quenched activity-based probe. J Am Chem Soc. 2013 Jan 9;135(1):174-82. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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