Mexiprostil
Mexiprostil (MDL 646) is an orally active gastric protectant, being a synthetic analogue of Prostaglandin E1 (HY-B0131). Mexiprostil exhibits significant inhibition of gastric acid secretion caused by Histamine (HY-B1204) and Bethanechol (HY-B0406) in rats, dogs, and cats. Mexiprostil can also inhibit the increase in gastric acid secretion caused by Pentagastrin (HY-A0261) in cats, while it does not have this effect in dogs and rats. Mexiprostil does not cause pregnancy termination. Mexiprostil can be used for research on gastric ulcers.
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- CAS. Nr.: 88980-20-5
- Formel: C23H40O6
- Molecular Weight:412.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Chemical Information
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CAS. Nr. 88980-20-5
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Molecular Weight 412.56
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Formel C23H40O6
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SMILES
CCCCC(OC)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(OC)=O
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Synonyms
MDL 646
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Müller P, et al. An alprostadil analogue and human gastric secretion. A double-blind placebo-controlled study of the effects of a capsule and tablet formulation. Arzneimittelforschung. 1989 Jul;39(7):809-11. [Content Brief]
[2]. Scarpignato C, et al. Action of MDL 646, a new synthetic prostaglandin, on gastric acid secretion of some experimental animals. Res Commun Chem Pathol Pharmacol. 1983 Feb;39(2):211-28. [Content Brief]
[3]. Galliani G, et al. Studies on the luteolytic activity of MDL-646, a new gastroprotective PGE1 analogue, in the hamster. Prostaglandins. 1984 Apr;27(4):583-90. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)