Migrastatin
Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration.
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- CAS. Nr.: 314245-65-3
- Formel: C27H39NO7
- Molecular Weight:489.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Fascin1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
14 μM
Compound: 3, migrastatin
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Inhibition of cell migration of mouse 4T1 cells after 4 days by scratch wound healing assay
Inhibition of cell migration of mouse 4T1 cells after 4 days by scratch wound healing assay
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[PMID: 18684620] |
| 4T1 | IC50 |
5.8 μM
Compound: 3, migrastatin
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Cytotoxicity against human mouse 4T1 cells
Cytotoxicity against human mouse 4T1 cells
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[PMID: 18684620] |
| MDA-MB-231 | IC50 |
17 μM
Compound: 3, migrastatin
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Inhibition of human MDA-MB-231 cell migration after 4 days by scratch wound healing assay
Inhibition of human MDA-MB-231 cell migration after 4 days by scratch wound healing assay
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[PMID: 18684620] |
| MDA-MB-231 | IC50 |
4.6 μM
Compound: 3, migrastatin
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Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
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[PMID: 18684620] |
Migrastatin (100 μM) leads to the disorganization of the bundles. Migrastatin (100 μM; HCT-116 and DLD-1 cells) prevents cell migration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 314245-65-3
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Molecular Weight 489.60
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Formel C27H39NO7
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SMILES
O=C(NC(C1)=O)CC1CCCC([C@H]([C@]2([H])/C(C)=C\[C@H]([C@@H]([C@H](/C=C/CC/C=C/C(O2)=O)OC)O)C)C)=O
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Structure Classification
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Initial Source
Streptomyces sp. MK929-43F1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Montoro-García S, et al. Novel anti-invasive properties of a Fascin1 inhibitor on colorectal cancer cells. J Mol Med (Berl). 2020;98(3):383-394. [Content Brief]
[2]. Nakae K, et al. Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2000;53(10):1130-1136. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Migrastatin Related Classifications
HY-121452 Related Classifications
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