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Art. -Nr.: HY-162822

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P-gp modulator-5

P-gp modulator-5 (compound 25) is a modulator of P-gp and can inhibit the proliferation of multidrug resistant (MDR) tumors. P-gp modulator-5 inhibits the activity of drug efflux pumps in MDR cells, leading to a large accumulation of ROS and altered cell cycle profiles.

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Formel: C₁₉H₁₆N₂O₅
Molecular Weight:352.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

P-gp modulator-5 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.22 μM Compound: 25	Inhibition of human A549 cells incubated for 48 hrs by SRB method Inhibition of human A549 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
COLO 205	GI₅₀	0.16 μM Compound: 25	Inhibition of cell growth in human COLO 205 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human COLO 205 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
DLD-1	GI₅₀	0.61 μM Compound: 25	Inhibition of cell growth in human DLD-1 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human DLD-1 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
H322	GI₅₀	0.174 μM Compound: 25	Inhibition of human H322 cells incubated for 48 hrs by SRB method Inhibition of human H322 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
K562	GI₅₀	0.25 μM Compound: 25	Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
LOX IMVI	GI₅₀	0.19 μM Compound: 25	Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB method Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB method	[PMID: 39093920]
MCF7	GI₅₀	0.15 μM Compound: 25	Inhibition of cell growth in human MCF7 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human MCF7 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
MRC5	GI₅₀	1.53 μM Compound: 25	Cytotoxicity against human MRC5 cells incubated for 48 hrs by SRB method Cytotoxicity against human MRC5 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
NCI/ADR-RES	GI₅₀	0.23 μM Compound: 25	Inhibition of cell growth in human NCI-ADR-RES cells incubated for 48 hrs by SRB method Inhibition of cell growth in human NCI-ADR-RES cells incubated for 48 hrs by SRB method	[PMID: 39093920]
NCI-H460	GI₅₀	0.35 μM Compound: 25	Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
OVCAR-3	GI₅₀	0.048 μM Compound: 25	Inhibition of cell growth in human OVCAR-3 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human OVCAR-3 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
OVCAR-8	GI₅₀	0.24 μM Compound: 25	Inhibition of cell growth in human OVCAR-8 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human OVCAR-8 cells incubated for 48 hrs by SRB method	[PMID: 39093920]
UACC-62	GI₅₀	0.16 μM Compound: 25	Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB method Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB method	[PMID: 39093920]

Chemical Information

Molecular Weight 352.34
Formel C₁₉H₁₆N₂O₅
SMILES

O=C1C=C(C(C2=C(C(C)=[N+](C=C21)[O-])C(OC)=O)=O)NCC3=CC=CC=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Discovery of Potent Isoquinolinequinone N-Oxides to Overcome Cancer Multidrug Resistance

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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