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Pepinemab

(Synonyms: VX 15/2503)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Pepinemab (VX 15/2503) is a human monoclonal antibody against SEMA4D, a signalling protein 4D (SEMA4D), also known as CD100, which is a regulator of neuronal development and plays a role in a variety of cellular processes. Pepinemab can be used in the study of various neurodegenerative diseases such as Alzheimer's disease by blocking the activity of SEMA4D.

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  • Reinheit: ≥99.0%
  • CAS. Nr.: 2097151-87-4
  • Molecular Weight:145.88 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pepinemab
  • Experimental Validation Results for Pepinemab
  • Experimental Validation Results for Pepinemab
  • Pepinemab Chemical Structure
  • Experimental Validation Results for Pepinemab
  • Experimental Validation Results for Pepinemab
  • Experimental Validation Results for Pepinemab
  • Pepinemab Chemical Structure
    Pepinemab Chemical Structure
CAS. Nr.: 2097151-87-4
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized Semaphorin-4D/SEMA4D Protein, Human (HEK293, His, HY-P7774) can bind Pepinemab. The EC50 for this effect is 52.14 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells with Pepinemab (HY-P99407, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Pepinemab Chemical Structure
    1/16
  • Pepinemab
  • Immobilized Semaphorin-4D/SEMA4D Protein, Human (HEK293, His, HY-P7774) can bind Pepinemab. The EC50 for this effect is 52.14 ng/mL.
  • Flow cytometric analysis of 1X106 Jurkat cells with Pepinemab (HY-P99407, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).