Art. -Nr.: HY-107482

Picamilon

(Synonyms: Nicotinoyl-GABA; Nicotinoyl-γ-aminobutyric acid)

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Picamilon is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227)-induced diabetes mellitus in rats.

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Reinheit: 98.25%
CAS. Nr.: 34562-97-5
Formel: C₁₀H₁₂N₂O₃
Molecular Weight:208.21

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Picamilon Chemical Structure

CAS. Nr.: 34562-97-5

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

Picamilon (PM) (20 or 50 mg/kg; i.p.) significantly decreases the frequency and duration of seizure spike-wave discharges (SWDs) in Picrotoxin (HY-101391)-induced convulsive activity in rats^[2].
Picamilon (250 mg/kg; p.o.) inhibits NLRP3 inflammasome activation in pancreatic cells during Alloxan (HY-W017227) -induced diabetes mellitus rats model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Picrotoxin (HY-101391)-induced epilepsy model in rats ^[2]
Dosage:

20 or 50 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Significantly decreased the frequency and duration of seizure spike-wave discharges (SWDs) in doses of 50 mg/kg.
Decreased the intensity of SWDs in smaller doses (20 mg/kg).

Animal Model:

Alloxan (HY-W017227)-induced diabetes mellitus model in rats ^[3]
Dosage:

250 mg/ kg
Administration:

Oral gavage (p.o.)
Result:

Suppressed NLRP3 activity, as indicated by a significant decrease in the area of immunopositive pancreatocytes to (21,30 ± 5,44) and (39,31 ± 5,24) %, respectively, relative to the value in the group of animals that were not treated (75,19±7,69%).
Promoted correction of functional disorders of the pancreas during alloxan-induced diabetes mellitus by inhibiting activation of NLRP3 inflammasome in pancreatocytes.

Chemical Information

CAS. Nr. 34562-97-5
Appearance Solid
Molecular Weight 208.21
Formel C₁₀H₁₂N₂O₃
Color White to off-white
SMILES

OC(CCCNC(C1=CN=CC=C1)=O)=O
Synonyms

Nicotinoyl-GABA; Nicotinoyl-γ-aminobutyric acid
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 62.5 mg/mL (300.18 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.8028 mL

24.0142 mL

48.0284 mL

5 mM

0.9606 mL

4.8028 mL

9.6057 mL

10 mM

0.4803 mL

2.4014 mL

4.8028 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mirzoian RS, et al. Vliianie pikamilona na krovosnabzhenie kory i mikrotsirkuliatsiiu v sisteme pial'nykh arteriol [Effect of pikamilon on the cortical blood supply and microcirculation in the pial arteriole system]. Biull Eksp Biol Med. 1989 May;107(5):581-2. Russian. [Content Brief]

[2]. Denisenko, et al. Effects of Picamilon and Isopicamilon on the Formation of Picrotoxin-Induced Convulsive Activity in Rats. Neurophysiology 46, 284–287 (2014).

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.8028 mL	24.0142 mL	48.0284 mL	120.0711 mL
	5 mM	0.9606 mL	4.8028 mL	9.6057 mL	24.0142 mL
	10 mM	0.4803 mL	2.4014 mL	4.8028 mL	12.0071 mL
	15 mM	0.3202 mL	1.6009 mL	3.2019 mL	8.0047 mL
	20 mM	0.2401 mL	1.2007 mL	2.4014 mL	6.0036 mL
	25 mM	0.1921 mL	0.9606 mL	1.9211 mL	4.8028 mL
	30 mM	0.1601 mL	0.8005 mL	1.6009 mL	4.0024 mL
	40 mM	0.1201 mL	0.6004 mL	1.2007 mL	3.0018 mL
	50 mM	0.0961 mL	0.4803 mL	0.9606 mL	2.4014 mL
	60 mM	0.0800 mL	0.4002 mL	0.8005 mL	2.0012 mL
	80 mM	0.0600 mL	0.3002 mL	0.6004 mL	1.5009 mL
	100 mM	0.0480 mL	0.2401 mL	0.4803 mL	1.2007 mL

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Picamilon

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Anti-diabetic Compound Library

Orally Active Compound Library

Neurotransmitter Receptor Compound Library

Anti-Alzheimer's Disease Compound Library

Neuroprotective Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Antidepressant Compound Library

GABA Receptor Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Extracellular Vesicles (EVs) Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

MCE Kinase Hinge Binder Fragment Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Picamilon

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Anti-diabetic Compound Library

Orally Active Compound Library

Neurotransmitter Receptor Compound Library

Anti-Alzheimer's Disease Compound Library

Neuroprotective Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Antidepressant Compound Library

GABA Receptor Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Extracellular Vesicles (EVs) Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

MCE Kinase Hinge Binder Fragment Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Picamilon Related Classifications

HY-107482 Related Classifications